Actively Recruiting
Surveillance Colonoscopy in Older Adults: The SurvOlderAdults Study
Led by VA Office of Research and Development · Updated on 2026-05-12
130000
Participants Needed
2
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Colorectal cancer is a leading cause of cancer death. Detection and removal of polyps can reduce risk for developing colorectal cancer. After finding and removing precancerous polyps, repeat colonoscopy is routinely recommended. However, it is unclear whether repeat additional colonoscopy further reduces risk for colorectal cancer. For older adults age 75 and older, the lack of this information is especially important, given that the risks of colonoscopy go up with age. This research will evaluate whether older adults with a prior history of precancerous polyps have higher colorectal cancer risks compared to older adults who had a prior normal colonoscopy, and whether, among those with prior precancerous polyps, repeating a colonoscopy after age 75 is associated with reduced cancer risk. The investigators will synthesize these data and gather perspectives from Veterans and clinical stakeholders to make recommendations on whether older adults with a prior history of polyps should continue or defer colonoscopy after age 75.
CONDITIONS
Official Title
Surveillance Colonoscopy in Older Adults: The SurvOlderAdults Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans alive at age 75 between 2005-2019 with a qualifying colonoscopy in the 10 years before turning 75
- Colonoscopy reports processed by natural language processing pipelines
- Colonoscopy closest to, but before age 75 is considered qualifying
- For Aim 2, Veterans age 75 or older between 2003-2019 with polypectomy before age 75
- Patients for interviews are age 75 with colonoscopy and polypectomy in past 10 years and referred for surveillance colonoscopy
- Providers include primary care, geriatrics, and gastroenterologists from VA sites
- Expert panel includes VA patients, providers, leadership, researchers, and others
You will not qualify if you...
- History of colorectal cancer before age 75
- History of sessile serrated adenoma/polyp/lesion, traditional serrated adenoma, or large serrated polyp at qualifying colonoscopy
- History of inflammatory bowel disease before age 75
- No exposure to normal colonoscopy or colonoscopy with polypectomy between ages 65-75
- Absence of reviewable colonoscopy note for cases and subcohort
- Absence of polypectomy with adenoma diagnosis at qualifying colonoscopy
- History of hereditary cancer syndrome (for Aim 2)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002
Actively Recruiting
2
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States, 90073-1003
Actively Recruiting
Research Team
S
Samir Gupta, MD MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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