Actively Recruiting
Surviving the Pediatric Intensive Care Unit (PICU)
Led by KK Women's and Children's Hospital · Updated on 2026-05-05
404
Participants Needed
2
Research Sites
146 weeks
Total Duration
On this page
Sponsors
K
KK Women's and Children's Hospital
Lead Sponsor
N
National University Hospital, Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
Improvement in pediatric intensive care unit (PICU) supportive care has led to improvement in clinical outcomes and decreased mortality in pediatric critical illness. However, PICU survivors are at risk of long-term health sequalae. Given the increased recognition of physical, cognitive, and psychological sequelae in PICU survivors, the concept of post-intensive care syndrome-pediatrics (PICS-p) has been proposed. Besides the PICU patient/survivor, the PICS-p framework also highlights the impacts of a child's critical illness has on the family. The impact of a PICU admission extends beyond the patient and parents, potentially affecting healthy siblings who are navigating their own developmental challenges. Healthy siblings may face emotional distress, increased responsibilities, and disruptions in their daily routines, all of which can contribute to long-term negative outcomes if unaddressed. Thus, this study consists of two cohorts to understand the long-term physical, cognitive, and psychological outcomes in PICU survivors and their families, and the short-term impacts on siblings of critically ill children.
CONDITIONS
Official Title
Surviving the Pediatric Intensive Care Unit (PICU)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For HOPE cohort: Children aged 28 days to 16 years at PICU admission
- Expected PICU stay longer than 48 hours
- For SHACK-S cohort: Healthy children aged 4 to 16 years with a critically ill sibling aged 28 days to 16 years
- Siblings must live in the same household as the critically ill child and parents prior to admission
You will not qualify if you...
- For HOPE cohort: Do-Not-Resuscitate status
- Lack of informed consent
- Prior enrollment in the study
- For SHACK-S cohort: Siblings of critically ill children with Do-Not-Resuscitate status
- Siblings with complex chronic conditions or neurocognitive/neurodevelopmental delays or disorders
- Previous PICU admission
- Lack of informed consent
- Prior enrollment in the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
National University Singapore
Singapore, Singapore, Singapore, 119074
Actively Recruiting
2
KK Women's and Children's Hospital
Singapore, Singapore, Singapore, 229899
Actively Recruiting
Research Team
E
Eric Jia Yong Ong, BSc (Hons)
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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