Actively Recruiting
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
Led by Brigham and Women's Hospital · Updated on 2025-11-24
310
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if the DSD model (SUSTAIN-DSD) is effective in improving participants HIV treatment adherence. The main questions it aims to answer are: * Does the SUSTAIN-DSD intervention significantly improve participants' treatment adherence and increase rates of viral suppression? * Does the SUSTAIN-DSD intervention help retain people in care? * Does SUSTAIN-DSD intervention help reduce the length of treatment interruptions? * for 24 months, Participants will either receive the SUSTAIN-DSD intervention (i.e. be enrolled in an adherence club where the participants will pick up 6-months of ART medication and have the option to use peer support and additional counseling), and or enhanced standard of care (i.e. visit the clinic for treatment and participate in optional counseling sessions). Blood will be drawn from the participants at the adherence club visits for viral load tests at baseline and every 12 months. \- Participants will take part in interviews to discuss the participants' experience with the SUSTAIN-DSD intervention.
CONDITIONS
Official Title
The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (≥18 years of age)
- Living with HIV
- Currently on a dolutegravir-based first-line ART regimen
- Evidence of a care gap (>28 days late for appointment) or a raised viral load (≥50 copies/ml) in the past year
- Able to provide full informed consent
- Willing to comply with study procedures, including providing updated contact details
You will not qualify if you...
- Clinical conditions requiring clinic-based follow-up such as tuberculosis or epilepsy
- Pregnant at enrollment and requiring antenatal clinic care
- Sustained retention in care without gaps >28 days and viral suppression in the past year
- Plans to leave Cape Town permanently within 24 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Cape Town
Cape Town, South Africa
Actively Recruiting
Research Team
I
Ingrid T Katz, MD, MHS
CONTACT
T
Trishathi Malagar Nandakumar, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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