Actively Recruiting
Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda
Led by Washington University School of Medicine · Updated on 2025-11-05
600
Participants Needed
2
Research Sites
219 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
M
Makerere University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study will employ a multilevel combination intervention focused on PrEP initiation and adherence among adolescent girls and young women (AGYW) (aged 15-24) living in HIV hotpots in Uganda. Specifically, the study will combine: 1) HIV risk reduction (HIVRR) that incorporates sessions on PrEP, 2) Peer Supporters (PS) with lived experiences taking PrEP to facilitate linkage to and continued care, share strategies to address misconceptions, manage disclosure and stigma, and model positive lifestyles while engaging in care services, and 3) an economic empowerment (EE) component that includes a matched savings account and financial literacy targeting poverty and financial barriers associated with PrEP access. Working within 30 health care systems, we will randomly assign 600 AGYW (at the community level) to one of three study arms (n=200 AGYW, n=10 sites per arm): 1) HIVRR only, 2) HIVRR+ PS, or 3) HIVRR + PS + EE. The interventions will be implemented for 20 months, and data collected at baseline, 12, 24, 36 months.
CONDITIONS
Official Title
Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 15-24 years
- At high risk of HIV by reporting at least one of the following in the past six or twelve months: vaginal/anal sex with multiple partners of unknown HIV status, sex without a condom, sex for money/goods/services, injecting drugs, multiple STI diagnoses, post-exposure prophylaxis for HIV, or having an HIV-positive partner not on ART
You will not qualify if you...
- HIV positive
- Unable to understand study procedures or participant rights during consent
- Unwilling or unable to complete the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Washington University in St. Louis
St Louis, Missouri, United States, 63130
Active, Not Recruiting
2
International Center for Child Health and Development (ICHAD)
Masaka, Uganda
Actively Recruiting
Research Team
F
Fred M Ssewamala, PhD
CONTACT
P
Proscovia Nabunya
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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