Actively Recruiting
SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants
Led by University of Arizona · Updated on 2026-04-16
46
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
Sponsors
U
University of Arizona
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to look at how the proteins and genes in people's skin change when they're exposed to simulated sunlight. The researchers want to see if there are differences between people who've had skin cancer and those who haven't despite having a similar type of skin and history of sun exposure. Since this study is designed to simulate sun exposure to small areas of skin, mild to moderate sunburn and tanned spots at the site of the simulated sunlight exposure is a risk. In addition to simulated sun exposure, patients will also have four 6 mm punch skin biopsies performed. Brief discomfort may be felt when the local painkiller (lidocaine) is injected prior to skin biopsies; however, it is usually minimal. Participation in the study involves 4 visits to the clinic over the course of 4 weeks. Each visit will take no longer than 90 minutes.
CONDITIONS
Official Title
SUV PDL1/PD1 in Sun Damaged & Sun Protected Human Skin of Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals 40 years of age or older
- Balanced age within 5 years when pairing groups
- Moderate or severe photodamage of the skin on the forearms
- Fitzpatrick skin type II or III
- History of two or more cutaneous squamous cell carcinomas in the past 5 years or no history of cSCC
- Females of childbearing potential must have a pregnancy test and use effective birth control during the study
- Willingness to limit sun exposure and wear protective clothing
- Ability to understand and sign informed consent
You will not qualify if you...
- Inflammation or irritation of the skin at test areas, or skin conditions like psoriasis or atopic dermatitis in those areas
- History of untreated skin cancer or melanocytic lesions in test areas
- Invasive cancer, chemotherapy, or radiation therapy within 5 years
- Immunosuppression from medication or disease
- Serious illness or psychiatric conditions interfering with study compliance
- Use of photosensitizing drugs within 30 days before enrollment or during the study
- Use of topical medications other than emollients or sunscreen on test areas within 30 days before enrollment
- Use of retinoids, steroids, 5-fluorouracil, and other specified topical treatments within 30 days before enrollment
- Use of mega-doses of vitamins exceeding standard limits within 30 days before enrollment
- Deliberate sun exposure (tanning) within 30 days before enrollment
- Fitzpatrick skin type I, IV, V, or VI
- Current enrollment in another clinical trial without a 30-day gap
- Known allergy to lidocaine
- Pregnant or nursing females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Arizona Cancer Center
Tucson, Arizona, United States, 85719
Actively Recruiting
Research Team
S
Stephanie Soto
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here