Actively Recruiting
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
Led by Wageningen University · Updated on 2026-02-27
60
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
Sponsors
W
Wageningen University
Lead Sponsor
F
Food & Biobased Research - Wageningen UR
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and preference, and the excretion of NNS in urine.
CONDITIONS
Official Title
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 to 79 years
- Body mass index (BMI) between 20 and 35 kg/m2
- Veins suitable for placement of a venflon catheter
You will not qualify if you...
- Diseases or prior surgeries affecting stomach, liver, kidneys, or intestines (except appendectomy)
- Cardiovascular diseases or cancer (non-invasive skin cancer allowed)
- Diagnosed with type 1 or type 2 diabetes
- Use of drug treatment for thyroid diseases (well-substituted hypothyroidism allowed)
- HbA1c level above 6.5% measured during screening
- Anemia defined as hemoglobin below 8.5 mmol/L for men and below 7.5 mmol/L for women
- Regular use of medication interfering with study outcomes (e.g., glucose lowering drugs, insulin, gastrointestinal affecting drugs)
- Use of antibiotics within 3 months before study start
- Blood donation within 2 months before screening
- Food allergies or intolerances to study products or dietary restrictions interfering with the study
- Following diets interfering with study outcomes within 1 month before screening (e.g., ketogenic, sugar free, carbohydrate free)
- Unwillingness to eat all study diet products including eggs and dairy (vegetarian possible)
- Unwillingness to consume non-nutritive sweeteners
- Unwillingness to stop supplements that interfere with study outcomes (e.g., pre- or probiotics)
- Intention to change exercise intensity or join intensive sport events during study
- Intention to lose or gain weight
- Regular night shift work
- Regular smoking
- Use of soft or hard drugs including cannabis
- Alcohol abuse defined as more than 14 drinks per week for women or more than 21 drinks per week for men
- Pregnancy, lactation, or planning pregnancy
- Inability to understand study information or communicate with staff
- Participation in another intervention study within 2 months prior to this study
- Working or doing thesis/internship at the Human Nutrition & Health division or Food, Health & Consumer Research group at Wageningen Food & Biobased Research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wageningen University & Research
Wageningen, Gelderland, Netherlands, 6708WG
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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