Actively Recruiting
Swiss Cardiac Amyloidosis REgistry (Swiss-CARE)
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2025-05-06
300
Participants Needed
7
Research Sites
1575 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cardiac transthyretin amyloidosis (ATTR), caused by ventricular depositions of misfolded transthyretin, results in an infiltrative cardiomyopathy, progressing from pronounced myocardial wall thickening, diastolic and systolic dysfunction to the development of terminal heart failure. Recently, treatment options for TTR amyloidosis have become available. However costs for therapy are enormous and previous trials were not able to differentiate between patients that might benefit from treatment and those without a need for treatment. the investigators study aims to determine markers, as assessed by cardiac magnet resonance imaging (CMR) feature tracking (FT) and T1- and T2- mapping, that might reliably indicate disease severity and could help to identify patients that might benefit from (ongoing) TTR stabilization treatment.
CONDITIONS
Official Title
Swiss Cardiac Amyloidosis REgistry (Swiss-CARE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of amyloidosis with or without heart involvement
- Ability to provide general consent
You will not qualify if you...
- Unable to provide consent or has a written or documented oral refusal to share data
- Younger than 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
USB
Basel, Switzerland, 4031
Not Yet Recruiting
2
Department of Cardiology, University Hospital Bern, Inselspital, Bern
Bern, Switzerland, 3010
Actively Recruiting
3
HUG
Geneva, Switzerland, 1211
Actively Recruiting
4
CHUV
Lausanne, Switzerland, 1011
Actively Recruiting
5
LUKS
Lucerne, Switzerland, 6000
Actively Recruiting
6
KSSG
Sankt Gallen, Switzerland, 9007
Actively Recruiting
7
Stadtspital Triemli
Zurich, Switzerland, 8063
Actively Recruiting
Research Team
C
Christoph Gräni, MD, PhD
CONTACT
M
Moritz Hundertmark, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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