Actively Recruiting
The Switching Antiplatelet-9 (SWAP-9) Study
Led by University of Florida · Updated on 2026-02-25
90
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare the pharmacodynamic effects of ABCD-GENE guided vs. unguided de-escalation strategies among patients on dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI).
CONDITIONS
Official Title
The Switching Antiplatelet-9 (SWAP-9) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who have undergone PCI and are on maintenance treatment with dual antiplatelet therapy composed of low-dose aspirin (81 mg daily) with either prasugrel (10 mg daily) or ticagrelor (90 mg twice daily)
- Patients who had PCI for acute coronary syndrome are eligible after at least 90 days post-PCI
- Patients who had PCI for chronic coronary syndrome are eligible after at least 30 days post-PCI
- Age 18 years or older
- Provide written informed consent
You will not qualify if you...
- Prior history of stent thrombosis
- PCI within the last 30 days
- Current treatment with any oral anticoagulant medication (vitamin K antagonists, dabigatran, rivaroxaban, apixaban, edoxaban) or chronic low-molecular-weight heparin for venous thrombosis treatment
- Hemodynamic instability
- Known hypersensitivity to clopidogrel
- Known platelet count less than 80 x 10^6/mL
- Known hemoglobin less than 9 g/dL
- Pregnant or breastfeeding women (women of childbearing age must use reliable birth control while participating)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Jacksonville, Florida, United States, 32209
Actively Recruiting
Research Team
L
Luis Ortega, MD, PhD
CONTACT
A
Andrea Burton, MPH, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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