Actively Recruiting
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
Led by University of Florida · Updated on 2026-02-05
48
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention. The purpose of this study is to conduct a head-to-head comparison on the pharmacodynamic efficacy of ticagrelor-based and prasugrel-based single antiplatelet therapy. To determine if the PD profiles of ticagrelor- and prasugrel-based SAPT are comparable, we aim to conduct a non-inferiority study between the two strategies.
CONDITIONS
Official Title
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients on dual antiplatelet therapy with aspirin plus prasugrel 10 mg or ticagrelor 90 mg twice daily for at least 90 days after PCI
- Age between 18 and 75 years old
- Able to provide written informed consent
You will not qualify if you...
- History of stent thrombosis
- PCI within the last 90 days
- History of stroke or transient ischemic attack (TIA)
- Age over 75 years old
- Weight less than 60 kg
- History of intracranial hemorrhage
- Current treatment with oral anticoagulants or chronic low-molecular-weight heparin for venous thrombosis
- Known coagulation disorders
- Severe liver impairment
- Allergic reaction to prasugrel or ticagrelor
- Pregnant or breastfeeding; persons of childbearing potential must use reliable birth control and will have pregnancy testing prior to participation
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Florida Jacksonville
Jacksonville, Florida, United States, 32209
Actively Recruiting
Research Team
F
Francesco Franchi, MD
CONTACT
A
Andrea Burton
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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