Actively Recruiting
SY001 Targets Mesothelin in a Single-arm, Dose-increasing Setting in Subjects With Advanced Solid Tumors
Led by Cell Origin Biotech (Hangzhou) Co., Ltd. · Updated on 2026-02-13
2
Participants Needed
2
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Single-arm, dose-increasing setting study of CAR macrophages in Mesothelin overexpressing solid tumors.
CONDITIONS
Official Title
SY001 Targets Mesothelin in a Single-arm, Dose-increasing Setting in Subjects With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with advanced ovarian or pancreatic cancer confirmed by pathology who have failed at least one prior treatment and have tumors positive for mesothelin staining
- Measurable tumor lesions as defined by RECIST 1.1 criteria on CT or MRI scans
- Eastern Cooperative Oncology Group (ECOG) performance status score of 2 or better with adequate major organ function
- Estimated life expectancy greater than 3 months
- Female patients of childbearing potential must have a negative serum pregnancy test before treatment and agree to use effective contraception for 1 year after the last study treatment
You will not qualify if you...
- Pregnant or breastfeeding women
- Uncontrolled active infections including tuberculosis or hepatitis B virus infection
- History of prior therapy targeting mesothelin
- History of autoimmune disease
- Patients unable or unwilling to follow the study protocol as assessed by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
2
Linyi Cancer Hospital
Linyi, China
Not Yet Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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