Actively Recruiting
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Led by University of Texas Southwestern Medical Center · Updated on 2025-08-24
100
Participants Needed
1
Research Sites
267 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
CONDITIONS
Official Title
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Control group: BMI less than 30, age 18 to 55 years
- Hypertensive group: BMI less than 30, age 18 to 55 years, diagnosed hypertension by 24-hour ambulatory blood pressure monitoring
- Obese group: BMI greater than 30, age 18 to 55 years
- Obese-hypertensive group: BMI greater than 30, age 18 to 55 years, diagnosed hypertension by 24-hour ambulatory blood pressure monitoring
You will not qualify if you...
- Presence of other significant cardiovascular disease
- Presence of renal (kidney) disease
- History of smoking
- Diagnosis of diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
C
Christopher M Hearon, Ph.D.
CONTACT
M
Mary Childers
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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