Actively Recruiting
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Led by University of Kansas Medical Center · Updated on 2025-06-08
23
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the excessively high prevalence of hypertension and risk for cardiovascular disease (CVD). This study is testing the health of the blood vessels and the activity of the nerves that control the blood vessels in adults with insulin resistance. The extent to which ascorbic acid (Vitamin C) improves the function of the blood vessels will be determined. The primary outcome is blood pressure, which is the result of blood vessel health and activity of the nerves, and the reduction in blood pressure that is observed with ascorbic acid.
CONDITIONS
Official Title
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Obese with BMI greater than 30
- Aged between 35 and 65 years
- Willing and able to stop taking vitamin C, vitamin E, or omega-3 supplements two weeks before the study
- Able and willing to provide written informed consent
You will not qualify if you...
- Diagnosis of diabetes mellitus (fasting glucose ≥ 1267 mg/dL or HbA1c ≥ 6.5%)
- Currently taking statin or antihypertension medication
- Hyperlipidemia with fasting triglycerides ≥ 250 mg/dL
- Hypertension with blood pressure ≥ 130/80 mmHg
- History of heart disease such as myocardial infarction or stent placement
- History of vascular disease such as bypass surgery or stroke
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
Research Team
S
Seth Holwerda, PhD
CONTACT
M
Manuel Clark, MPA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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