Actively Recruiting
Sympatholysis in Chronic Kidney Disease
Led by Emory University · Updated on 2025-03-05
110
Participants Needed
1
Research Sites
624 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).
CONDITIONS
Official Title
Sympatholysis in Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans with Stages III and IV Chronic Kidney Disease (CKD)
- Kidney transplant recipients with varying degrees of kidney function
- Veterans 18-75 years old, without kidney disease, as study controls
- Exercise less than 20 minutes twice per week
- Willing and able to cooperate with the protocol
You will not qualify if you...
- Severe CKD with estimated glomerular filtration rate (eGFR) less than 15 cc/minute
- Metabolic alkalosis with serum bicarbonate greater than 28 meq/L
- Ongoing drug or alcohol abuse
- Diabetic neuropathy
- Any serious systemic disease that might affect survival
- Severe anemia with hemoglobin level less than 10 g/dL
- Clinical evidence of congestive heart failure or ejection fraction below 35%
- Symptomatic heart disease based on ECG, stress test, or history
- Treatment with central alpha agonists (clonidine)
- Uncontrolled hypertension with blood pressure over 170/100 mmHg
- Low blood pressure under 100/50 mmHg
- Pregnancy or plans to become pregnant
- Current treatment with monoamine oxidase inhibitors (MAOIs)
- Inability to exercise on a stationary bicycle
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atlanta VA Medical Center
Decatur, Georgia, United States, 30033
Actively Recruiting
Research Team
D
Dana DaCosta
CONTACT
J
Jeanie Park, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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