Actively Recruiting
Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging
Led by University of Edinburgh · Updated on 2026-03-16
100
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
N
NHS Lothian
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with symptomatic peripheral arterial disease.
CONDITIONS
Official Title
Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged > 18 years
- Symptomatic atherosclerotic peripheral artery disease
- Intermittent claudication with ankle/arm blood pressure ratio <0.90 or artery stenosis >50% plus at least one of the following: >1 vascular bed affected by atherosclerosis, diabetes, heart failure, or chronic kidney disease (eGFR < 60 mL/min/1.73 m2)
- Rest pain, necrosis, or gangrene of limb
- History of limb bypass surgery or endovascular revascularization procedures including angioplasty/stent or extra-anatomical bypass surgery
- Leg or foot amputation for arterial vascular reasons
- Ability to give written or verbal informed consent
You will not qualify if you...
- Contraindication to colchicine or iodinated contrast
- Long-term colchicine use for other conditions
- Active diarrhea
- Recent lower limb revascularization for symptomatic disease (<6 weeks)
- Renal failure with glomerular filtration rate <30 mL/min/1.73 m2
- Cirrhosis or severe chronic liver disease
- Women who are pregnant or breastfeeding
- Women of child-bearing potential not using reliable contraception or planning conception during the study
- Current or planned long-term use of cyclosporine, verapamil, HIV protease inhibitors, azole antifungals, or macrolide antibiotics (except azithromycin)
- Patients unlikely to return for follow-up
- Life expectancy less than 1 year
- Inability or unwillingness to give informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Royal Infirmary of Edinburgh
Edinburgh, Midlothian, United Kingdom, EH16 4SA
Actively Recruiting
Research Team
A
Allison c Winarski, MBChB, MRCS(Ed)
CONTACT
R
Rachael O Forsythe, MBChB, PhD, FRCS (Vascular)
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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