Actively Recruiting
Symptoms and Quality of Life in Patients With Heterotopic Gastric Mucosa (HGM)
Led by Knappschaft Kliniken GmbH · Updated on 2026-04-14
721
Participants Needed
1
Research Sites
66 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn whether heterotopic gastric mucosa (HGM) in the upper esophagus is associated with swallowing difficulties (dysphagia) in adults undergoing a medically indicated gastroscopy. The main questions it aims to answer are: * Is the presence of HGM associated with dysphagia? * Is the presence of HGM associated with dyspepsia and reduced health-related quality of life? Among participants reporting dysphagia, what is the distribution of oropharyngeal versus esophageal dysphagia, and is this related to the presence of HGM? If there is a comparison group: Researchers will compare participants with endoscopically confirmed HGM to participants without HGM to determine whether dysphagia, dyspepsia symptoms, and quality-of-life measures differ between groups. Participants will: Complete pseudonymised questionnaires about dysphagia, dyspepsia symptoms, and quality of life before the gastroscopy. Undergo the medically indicated gastroscopy as planned; the endoscopist will assess whether HGM is present based on the endoscopic appearance, and routine endoscopy findings will be documented.
CONDITIONS
Official Title
Symptoms and Quality of Life in Patients With Heterotopic Gastric Mucosa (HGM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Planned upper gastrointestinal endoscopy (gastroscopy) for clinical reasons (any indication)
- Age 18 years or older
- Written informed consent
- Ability to complete the study questionnaires prior to endoscopy
You will not qualify if you...
- Previously known heterotopic gastric mucosa (HGM)
- Previously diagnosed dysphagia with prior therapeutic intervention (diet modification, partial oral/enteral nutrition, steroid therapy, botulinum toxin injection, etc.)
- Mechanical ventilation
- Presence of a tracheostomy
- Inadequate endoscopic assessability of the proximal esophagus (poor general condition, increased aspiration risk, poor visibility, complications preventing careful inspection)
- History of surgery involving the pharynx or esophagus
- Relevant severe neurological disorder (e.g., ALS, stroke)
- Severe dementia
- Severe depressive disorder
- Lack of cooperation or inability to comply with study procedures
- Planned PEG placement
- Emergency endoscopy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Knappschaftskrankenhaus Bottrop
Bottrop, North Rhine-Westphalia, Germany, 46240
Actively Recruiting
Research Team
F
Felix Horstmann, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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