Actively Recruiting
Synbiotic Compound to Reduce Symptoms of Schizophrenia
Led by Sheppard Pratt Health System · Updated on 2026-04-07
68
Participants Needed
1
Research Sites
301 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if taking a synbiotic supplement versus a placebo will reduce symptoms of schizophrenia when used in addition to standard antipsychotic medications.
CONDITIONS
Official Title
Synbiotic Compound to Reduce Symptoms of Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years
- Able to provide written informed consent
- Diagnosed with schizophrenia or schizoaffective disorder based on DSM-5 and SCID-5
- Outpatient status at enrollment
- Residual psychotic symptoms with PANSS total score of 60 or higher and specific positive symptom criteria
- On stable antipsychotic medication for at least 8 weeks with no changes in last 21 days
- Proficient in English
You will not qualify if you...
- Diagnosis of intellectual disability or similar
- Any clinically significant or unstable medical disorder such as congestive heart failure, liver disease, renal failure, or active cancer treatment
- Primary immunodeficiency or treatments affecting immune system
- History of intravenous drug use
- Moderate or severe substance use disorder (except caffeine or tobacco) within last 3 months
- Participation in any investigational drug trial within last 30 days
- Pregnant or planning pregnancy during study
- Antibiotic use within 14 days prior to randomization
- Current regular use of probiotic or prebiotic supplements within past 2 weeks
- Diagnosed inflammatory bowel disease or celiac disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sheppard Pratt Health System
Batlimore, Maryland, United States, 21285
Actively Recruiting
Research Team
E
Emily Katsafanas
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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