Actively Recruiting
SYNERGIC-2 Trial (SYNchronizing, Exercises and Remedies to GaIn Cognition@home)
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-10-29
275
Participants Needed
8
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In Canada, 1,700,000 adults are at risk of dementia, half of them with MCI,representing one of the largest groups at risk for an incurable disease. Epidemiological evidence suggests up to 40% of dementia cases might be preventable by targeting modifiable lifestyle and cardiovascular factors. Given that current treatments cannot modify the disease, prevention is critical. SYNERGIC-2 offers a "personalized multidomain intervention" that combines physical and cognitive training, sleep, diet, and vascular-metabolic interventions in individuals with MCI to synergistically enhance their overall brain health including cognition and contributes to maintaining their independence. Importantly, interventions will be provided at home using an existing virtual platform reducing delivery complexity and expanding the accessibility to a wider population, thus decreasing potential inequities. Improving older adults' brain health and achieving even a modest two-year dementia incidence delay will have a projected saving of $218 Billion in Canada's healthcare system over 30 years.
CONDITIONS
Official Title
SYNERGIC-2 Trial (SYNchronizing, Exercises and Remedies to GaIn Cognition@home)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 60 to 85 years
- Diagnosis of mild cognitive impairment (MCI) with subjective memory complaints and objective cognitive impairment but no dementia
- Preserved daily living activities based on cognitive abilities
- Montreal Cognitive Assessment (MoCA) score between 16 and 25 inclusive, and/or RAVLT delayed recall ≤6, and/or Clinical Dementia Rating Scale (CDR) = 0.5
- At least one additional dementia risk factor: low physical activity (<150 minutes/week), poor diet (Mediterranean Diet Assessment score ≤7), insomnia or subthreshold insomnia (Insomnia Severity Index score >7), or vascular-metabolic risk (CAIDE score ≥6, diabetes, obesity with BMI≥30, hypertension, or smoking)
- Access to a home computer, laptop, or tablet with internet and ability to use email and video conferencing
- Self-reported proficiency in English for speaking and understanding
- Normal or corrected vision in at least one eye
- Normal or corrected hearing ability
- Ability to comply with virtual visits, treatment plan, and study activities
- Ability to participate in exercise training as determined by the Get Active Questionnaire (GAQ)
You will not qualify if you...
- Diagnosis of dementia based on DSM-IV criteria
- Severe diseases or psychiatric diagnoses that prevent participation, including major depression (GDS-30 >19), schizophrenia, severe anxiety, neurological disorders with severe motor deficits, unstable chronic diseases like congestive heart failure or COPD, or advanced-stage active cancer
- Surgery within the last 2 months or planned surgery in the next 12 months that affects vision, hearing, mobility, or participation abilities
- Regular use of benzodiazepines or neuroleptic drugs interfering with assessments or interventions
- Recent or current substance or alcohol abuse in the past 12 months
- Transmural myocardial infarction within 6 months prior to enrollment that prevents physical activity
- Intention to enroll in other interventional clinical trials during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
University of Alberta
Edmonton, Alberta, Canada, T6G 2G3
Actively Recruiting
2
University of British Columbia
Vancouver, British Columbia, Canada
Actively Recruiting
3
University of New Brunswick
Fredericton, New Brunswick, Canada
Actively Recruiting
4
St. Joseph's Health Care London, Parkwood Hospital
London, Ontario, Canada, N6C5J1
Actively Recruiting
5
University of Ottawa
Ottawa, Ontario, Canada
Actively Recruiting
6
Baycrest Academy for Research and Education
Toronto, Ontario, Canada
Actively Recruiting
7
University of Waterloo
Waterloo, Ontario, Canada
Actively Recruiting
8
Concordia University
Montreal, Quebec, Canada
Actively Recruiting
Research Team
D
Diana Amaris
CONTACT
F
Frederico Faria, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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