Actively Recruiting

Phase Not Applicable
Age: 10Years - 18Years
All Genders
NCT05340881

Systematic Light Exposure in Pediatric Brain Tumor Survivors

Led by Baylor College of Medicine · Updated on 2025-09-18

40

Participants Needed

1

Research Sites

193 weeks

Total Duration

On this page

Sponsors

B

Baylor College of Medicine

Lead Sponsor

N

National Institute of Nursing Research (NINR)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Children and adolescents treated for a brain tumor often experience fatigue and cognitive symptoms, such as slowed information processing and inattention. These symptoms may cause difficulty carrying out daily activities at home and at school. There are few well-researched, non-pharmacological interventions aimed at improving symptoms of fatigue and by extension cognitive symptoms. Systematic bright light exposure has been shown to improve symptoms of fatigue in adult survivors of cancer and children treated for some forms of cancer. This is a pilot/feasibility study and the first known study in children treated for a brain tumor. Findings from this study will be used to help plan a larger study to examine the effectiveness of this intervention and mechanisms of action. PRIMARY OBJECTIVE: 1. To evaluate feasibility and adherence in a study of systematic bright light exposure used to improve fatigue and cognitive efficiency in survivors of pediatric brain tumor, including rates of enrollment, adherence, and acceptability. SECONDARY OBJECTIVES: 2. To estimate the effect size of change in fatigue associated with bright light exposure. 3. To estimate the effect size of change in cognitive efficiency associated with bright light exposure.

CONDITIONS

Official Title

Systematic Light Exposure in Pediatric Brain Tumor Survivors

Who Can Participate

Age: 10Years - 18Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed and treated for a brain tumor at Texas Children's Hospital
  • Treated with surgery only or surgery and proton beam radiation therapy
  • Diagnosed with tumors other than high-grade gliomas, brain stem gliomas, or atypical teratoid rhabdoid tumors
  • Currently or previously enrolled in longitudinal neurocognitive outcome studies for pediatric brain tumor survivors
  • Aged 10 to 18 years
  • At least 1 year since diagnosis
  • Reports mild to moderate fatigue symptoms on the PROMIS scale
  • Approved by Long-Term Survivorship provider
  • Adequate vision for computerized tests
  • English-speaking
  • Intelligence Quotient (IQ) above 70
Not Eligible

You will not qualify if you...

  • Diagnosis or treatment for a secondary cancer within the past 12 months
  • Current or recent (within 12 months) suicidal thoughts or severe depression needing immediate care
  • Presence of light sensitivity (photophobia), eye diseases, seizures, or migraines
  • Use of photosensitizing medications
  • Current or past use of light therapy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Texas Children's Hospital

Houston, Texas, United States, 77030

Actively Recruiting

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Research Team

K

Kimberly P Raghubar, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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