Screening Children for Primary Immune Deficiencies After Severe Infections in Pediatric Intensive Care Units

What this Trial Is About

Severe infections in children admitted to pediatric intensive care units are common, and there is growing interest in understanding whether genetic factors, such as primary immune deficiencies, contribute to these infections. This observational study aims to determine how often primary immune deficiencies are found in children with severe infections, regardless of the infection type. Researchers want to better understand the role of immune deficiencies in these serious cases. The study will include children aged between 3 months and 16 years who have a documented severe infection requiring hospitalization in pediatric intensive care for more than 24 hours. Eligible infections include those affecting the brain or meninges, lung infections, sepsis-related infections, and encephalitis. Parental or legal guardian consent will be obtained before participation. The study is conducted at University Hospital Centers in Montpellier, Toulouse, and Marseille. Participants will be closely monitored during their hospital stay. Researchers will assess the number of patients diagnosed with primary immune deficiencies after their severe infection. The sensitivity of the systematic screening method will also be evaluated. This study will help identify underlying immune problems in children with severe infections, supporting better diagnosis and care. The study started in September 2023 and is expected to continue until September 2026.

Systematic Screening for Primary Immunodeficiencies in Patients Admitted for Severe Infection in Pediatric Intensive Care Unit