Actively Recruiting
Systemic Lupus Erythematosus in Gullah Health
Led by Medical University of South Carolina · Updated on 2025-07-10
750
Participants Needed
1
Research Sites
1313 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunologic manifestations. African Americans are at a disproportionately higher risk of developing SLE, develop SLE at an earlier age, and have increased morbidity and mortality compared with European Americans. Our central study hypothesis is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. The African American Gullah population from the Sea Islands of South Carolina and Georgia are unique in their genetic homogeneity with minimal non-African genetic admixture, making them an ideal cohort to address questions of environmental and genetic influence on the development and progression of SLE.
CONDITIONS
Official Title
Systemic Lupus Erythematosus in Gullah Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 years and above
- Self-identified as African-American "Gullah" from the Sea Island region of South Carolina
- Have at least 4 of the 11 diagnostic criteria for SLE by the American College of Rheumatology, be a relative of a known SLE patient, or be an unrelated healthy Gullah control
- Ability to speak and understand English
- Ability and willingness to give informed consent
You will not qualify if you...
- Race defined by participant as other than Black or African-American
- Being a prisoner, mentally ill patient, or institutionalized individual
- Unwilling or unable to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
D
Diane L. Kamen, MD, MSCR
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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