Actively Recruiting
tACS to Enhance Language Abilities
Led by University of Pennsylvania · Updated on 2025-08-08
120
Participants Needed
1
Research Sites
215 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
CONDITIONS
Official Title
tACS to Enhance Language Abilities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of aphasia
- Single, left hemisphere stroke
- Stroke occurred 6 months or more before enrollment
- Right-handedness (for healthy controls)
- Ability to understand the study and give informed consent (for healthy controls)
You will not qualify if you...
- Inability to understand the study
- Marked naming impairment
- Impaired non-verbal, conceptual processing
- History of significant medical or neurological disorders other than stroke
- Significant or poorly controlled psychiatric disorders
- Current abuse of alcohol or drugs
- Nursing, pregnancy, or intent to become pregnant during the study
- Clinically significant hearing loss
- Contraindications to tACS
- Contraindications to MRI
- Diagnosis of neurodegenerative disease or significant cognitive complaints (healthy controls)
- Neurologic or physical conditions impairing communication ability (healthy controls)
- History of unrelated neurological conditions causing deficits (healthy controls)
- Neurological conditions reducing safety of participation (e.g., CNS vasculitis, tumors, aneurysm, multiple sclerosis)
- Medically unstable cardiopulmonary or metabolic disorder
- Terminal illness with expected survival under 12 months
- Major active psychiatric illness interfering with study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
D
Daniela Sacchetti, MS
CONTACT
D
Denise Harvey, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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