Study of Remote Exercise Training and Lifestyle Changes for Adults with Heart Failure with Preserved Ejection Fraction HFpEF

What this Trial Is About

Heart failure with preserved ejection fraction HFpEF is a condition linked to high rates of illness and death, with limited medication options. Exercise intolerance, causing breathlessness and tiredness, is a key symptom that lowers quality of life and raises hospitalization risk. This research focuses on adults with or at risk for HFpEF, aiming to assess the effects of different lifestyle exercise programs on exercise capacity and muscle health. The study has two phases. In Phase I, 120 participants will follow a three-month home-based moderate-intensity continuous training MCT program using customized exercise videos on a mobile device, with weekly virtual coaching sessions. This is followed by a three-month period without intervention to observe detraining effects. In Phase II, starting at six months, 100 participants will be randomly assigned to one of four groups for three months MCT alone MCT plus resistance training videos MCT plus weight loss medications or MCT combined with resistance training and weight loss medications. Participants will be involved in regular assessments including exercise testing, physical performance evaluations, and quality of life questionnaires at baseline, 3, 6, and 9 months. Imaging scans of the chest, abdomen, and pelvis will measure changes in muscle composition. The main outcomes measured are peak oxygen uptake during exercise and physical performance scores. Other health and muscle-related markers will also be tracked to understand the effects of the lifestyle interventions.

Tailored Exercise Training Study Among Adults With HFpEF