Actively Recruiting
Tailored Versus Coventional AntiPlaTelet Strategy Intended After OPTIMIZEd Drug Eluting Stent
Led by Asan Medical Center · Updated on 2026-03-30
3944
Participants Needed
25
Research Sites
323 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Objectives: To assess the safety of tailored antiplatelet therapy (short DAPT followed by P2Y12 inhibitor alone strategy) in patients who received optimized DES implantation guided by intravascular imaging (IVUS or OCT) Hypothesis: Tailored antiplatelet strategy (short DAPT followed by P2Y12 inhibitor alone) is superior to conventional antiplatelet strategy in terms of clinically relevant bleeding and noninferior for ischemic composite adverse events in patients who received intravascular imaging-guided optimized DES implantation. (Optimized stent evaluated by on-site IVUS/OCT could act as an essential criterion for decision making for tailored antithrombotic strategy)
CONDITIONS
Official Title
Tailored Versus Coventional AntiPlaTelet Strategy Intended After OPTIMIZEd Drug Eluting Stent
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women aged 19 years or older
- Typical chest pain or objective evidence of myocardial ischemia suitable for PCI
- Significant new coronary artery lesions suitable for DES implantation
- Patients who underwent optimized stent implantation guided by IVUS or OCT meeting specific imaging criteria
- Patient or guardian agrees to study protocol, follow-up schedule, and provides informed written consent
You will not qualify if you...
- Bypass graft lesions
- Lesions with expected impaired delivery of imaging catheters due to extreme angulation (≥90°), excessive tortuosity (≥ two 45° angles), or heavy calcification
- In-stent restenosis
- Hypersensitivity or contraindication to device materials including cobalt, chromium, nickel, platinum, tungsten, acrylic, and fluoro polymers
- Persistent thrombocytopenia (platelet count <80,000/µL)
- History of hemorrhagic stroke, intracranial hemorrhage, TIA, or ischemic stroke within past 6 months
- Known intolerance or hypersensitivity to aspirin, clopidogrel, ticagrelor, or heparin
- Requirement for long-term oral anticoagulants or cilostazol
- Planned surgery requiring general anesthesia or stopping aspirin/ADP antagonist within 12 months after procedure
- Diagnosis or treatment of cancer (other than superficial skin cancer) in past 3 years
- Clinically significant abnormalities at screening that preclude safe study completion
- History of liver cirrhosis (Child-Pugh B or C) or biliary tract obstruction
- Life expectancy less than 1 year from any cause
- Cardiogenic shock at index admission
- Pregnancy or breastfeeding
- Active bleeding or high risk for major bleeding (e.g., peptic ulcer disease, gastrointestinal pathology, malignancies with high bleeding risk)
- Unwillingness or inability to comply with study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
Bucheon Sejong Hospital
Bucheon-si, South Korea
Actively Recruiting
2
Dong-A University Hospital
Busan, South Korea
Actively Recruiting
3
Inje University Busan Paik Hospital
Busan, South Korea
Not Yet Recruiting
4
Kosin University Gospel Hospital
Busan, South Korea
Actively Recruiting
5
Gyeongsang National University Changwon Hospital
Changwon, South Korea
Actively Recruiting
6
Kangwon National University Hospital
Chuncheon, South Korea
Actively Recruiting
7
Chungbuk National University Hospital
Chungju, South Korea
Actively Recruiting
8
Daegu Catholic Univ Medical Center
Daegu, South Korea
Not Yet Recruiting
9
Keimyung University Dongsan Medical Center
Daegu, South Korea
Actively Recruiting
10
Kyungpook National University Hospital
Daegu, South Korea
Not Yet Recruiting
11
Veterans Hospital
Daegu, South Korea
Not Yet Recruiting
12
Gangneung Asan Hospital
Gangneung, South Korea
Actively Recruiting
13
Jeonbuk National University Hospital
Jeonju, South Korea
Actively Recruiting
14
Gyeongsang National University Hospital
Jinju, South Korea
Actively Recruiting
15
Chungnam National University Sejong Hospital
Jungnam, South Korea
Actively Recruiting
16
Dankook University Hospital
Jungnam, South Korea
Actively Recruiting
17
Asan Medical Center
Seoul, South Korea
Actively Recruiting
18
Kangbuk Samsung Hospital
Seoul, South Korea
Actively Recruiting
19
Korea University Anam Hospital
Seoul, South Korea
Actively Recruiting
20
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, South Korea
Not Yet Recruiting
21
Veterans Hospital Service Medical Center
Seoul, South Korea
Actively Recruiting
22
Ajou University Hospital
Suwon, South Korea
Actively Recruiting
23
The Catholic University of Korea, ST. Vincent's Hospital
Suwon, South Korea
Completed
24
Ulsan University Hospital
Ulsan, South Korea
Actively Recruiting
25
Pusan National University Yangsan Hospital
Yangsan, South Korea
Not Yet Recruiting
Research Team
J
Ji Sue Hong, RN
CONTACT
P
Pil Hyung Lee, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here