Actively Recruiting
Tailoring Treatment in Colorectal Cancer
Led by University Hospital, Akershus · Updated on 2024-08-06
40
Participants Needed
1
Research Sites
248 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Akershus
Lead Sponsor
O
Oncosyne AS
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study, the investigators will establish a reliable method and logistic pipeline for personalized drug testing ex vivo using fresh tumor samples from colorectal cancer (CRC) patients. With this, the investigators aim to develop a novel predictive biomarker of immunotherapy response, by testing combinations of chemotherapies and chimeric antigen receptor (CAR) T cells. Critically, this affects a large subgroup of patients currently not considered to benefit from such treatment. To support the hypothesis, the project will make use of cutting-edge, cell-based functional diagnostics. Individual patients' cancer cells will be screened against a panel of chemotherapies and targeted therapies including CAR T cells, to assess the optimal combination of therapies to induce immunotherapy efficacy in otherwise unresponsive CRC.
CONDITIONS
Official Title
Tailoring Treatment in Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed colorectal cancer scheduled for curative surgery and standard clinical follow-up.
You will not qualify if you...
- Unable or unwilling to sign the informed consent form.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Akershus University Hospital
Lørenskog, Akershus, Norway, 1478
Actively Recruiting
Research Team
S
Sebastian Meltzer, M.D. Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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