Actively Recruiting
Tampere Coronary Artery Disease and Sudden Cardiac Arrest Study
Led by Tampere Heart Hospital · Updated on 2025-02-03
4000
Participants Needed
1
Research Sites
782 weeks
Total Duration
On this page
Sponsors
T
Tampere Heart Hospital
Lead Sponsor
T
Tampere University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to identify clinical and genetic risk factors for sudden cardiac arrest (SCA) and sudden cardiac death (SCD) in people with coronary artery disease (CAD). It focuses on recognizing treatment-related and genetic risks in patients under 75 years old. The study is observational and recruits adults diagnosed with CAD, assessing their medical history and socioeconomic status to better understand these life-threatening events. Participants undergo a standard ECG plus a five-minute ECG recording along with several brief physiological tests such as blood pressure, height, weight, and grip strength. Blood samples are collected from selected participants under 76 years old, with additional genetic testing samples taken from some younger groups based on ECG results. The study uses healthcare records for long-term follow-up, with no required follow-up visits. During the study, researchers collect survey responses, physiological measurements, and blood samples, storing data securely. Medical records and national death certificates will be reviewed to identify cases of sudden cardiac death over a 15-year period. The main outcome measured is sudden cardiac death, with additional secondary endpoints also tracked. The study aims to enroll around 4,000 participants to detect meaningful associations in risk factors, with data analyzed using advanced statistical and machine learning methods.
CONDITIONS
Brief Title
Tampere Coronary Artery Disease and Sudden Cardiac Arrest Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Live in the Wellbeing Services County of Pirkanmaa
- Diagnosed with coronary artery disease by invasive coronary angiogram or CT angiogram evaluated by cardiologists
- Angiogram or CT angiogram performed within the last 3 months
- Have good or moderate everyday functional ability
You will not qualify if you...
- Life expectancy less than 1 month
- Significant valvular heart disease treated or planned treatment within 3 months
- Previously implanted or planned implant of cardioverter-defibrillator (ICD) within 3 months
- Active malignancy or ongoing cancer treatment
- Significant neurodegenerative disease or cognitive impairment affecting daily function
- Intellectual disability or significant cognitive disability
- Do-not-resuscitate (DNR) order or decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 15 years
Participants diagnosed with coronary artery disease are observed with data collected from medical records, surveys, physiological measurements, and blood samples. Sudden cardiac death (SCD) data is collected from the national death certificate register over the follow-up period.
Initial data collection visit with possible additional assessments based on medical records; no scheduled repeated visits
Trial Site Locations
Total: 1 location
1
Tampere University Hospital Tampere Heart Centre
Tampere, Pirkanmaa, Finland, 33100
Actively Recruiting
Research Team
J
Jussi Hernesniemi, Professor
J
Juho Tynkkynen, Medical Doctor, Phd
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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