Study on Clinical and Genetic Risk Factors for Sudden Cardiac Arrest in Adults with Coronary Artery Disease Observational Study at Tampere Heart Hospital with ECG and Blood Sample Analysis

What this Trial Is About

This research aims to identify clinical and genetic risk factors for sudden cardiac arrest SCA and sudden cardiac death SCD in people with coronary artery disease CAD. It focuses on recognizing treatment-related and genetic risks in patients under 75 years old. The study is observational and recruits adults diagnosed with CAD, assessing their medical history and socioeconomic status to better understand these life-threatening events. Participants undergo a standard ECG plus a five-minute ECG recording along with several brief physiological tests such as blood pressure, height, weight, and grip strength. Blood samples are collected from selected participants under 76 years old, with additional genetic testing samples taken from some younger groups based on ECG results. The study uses healthcare records for long-term follow-up, with no required follow-up visits. During the study, researchers collect survey responses, physiological measurements, and blood samples, storing data securely. Medical records and national death certificates will be reviewed to identify cases of sudden cardiac death over a 15-year period. The main outcome measured is sudden cardiac death, with additional secondary endpoints also tracked. The study aims to enroll around 4,000 participants to detect meaningful associations in risk factors, with data analyzed using advanced statistical and machine learning methods.

Tampere Coronary Artery Disease and Sudden Cardiac Arrest Study