Evaluating Tamsulosin Alone Versus Combined With Two Doses of Tadalafil for Urinary Symptoms in Men Over 45 with Enlarged Prostate

What this Trial Is About

This research aims to compare the short-term effects and clinical outcomes of tamsulosin alone versus combined with two different doses of tadalafil 2.5 mg and 5 mg in managing moderate to severe lower urinary tract symptoms LUTS caused by benign prostatic hyperplasia BPH in men aged 45 and older. The study focuses on symptom severity and quality of life, evaluating if lower tadalafil doses can relieve symptoms while reducing side effects over 12 weeks. Participants will be randomly assigned to one of three groups tamsulosin 0.4 mg daily alone, or tamsulosin 0.4 mg daily combined with tadalafil 2.5 mg or 5 mg daily. These medications are taken once daily for a treatment period of 12 weeks. The study uses a double-blind design to compare these approaches in a parallel-group format. During the 12-week study, participants will be monitored for changes in their International Prostate Symptom Score IPSS to assess symptom improvement. Researchers will also track any adverse events or side effects. Follow-up visits and assessments will evaluate the impact on patients quality of life and safety, with all participants receiving care under medical supervision throughout the study.

Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH