Actively Recruiting
Taper Or Abrupt Steroid Stop: TOASSTtrial
Led by University Hospital, Basel, Switzerland · Updated on 2026-04-22
530
Participants Needed
16
Research Sites
521 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
K
Kantonsspital Baselland Bruderholz
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is an Investigator-initiated, placebo-controlled, multicenter noninferiority trial, comparing rapid termination of systemic glucocorticoid treatment with a tapering regime over 4 weeks.
CONDITIONS
Official Title
Taper Or Abrupt Steroid Stop: TOASSTtrial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent
- Age 18 years or older
- Taking daily glucocorticoid dose of 7.5 mg prednisone-equivalent or higher at inclusion
- Glucocorticoid therapy for at least 28 days with an average daily dose of 7.5 mg or more and cumulative dose of at least 420 mg prednisone-equivalent before inclusion
- No longer needing tapering to treat the underlying disease
You will not qualify if you...
- Primary adrenal failure
- Treatment with systemic depot glucocorticoids (e.g., intramuscular, epidural)
- Unable to take glucocorticoid cover treatment during stress
- Unable or unwilling to provide informed consent
- Pregnant or breastfeeding women
- Planning to become pregnant during the study
- Lack of reliable contraception for women of childbearing potential
- Known or suspected non-compliance
- Unable to follow study procedures due to language, psychological, or cognitive issues
- Participation in another investigational drug study within 30 days before or during this study
- Previous enrollment in this study
- Investigator, family members, employees, or dependents enrolled
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
University Hospital Frankfurt
Frankfurt, Germany
Actively Recruiting
2
University Hospital Würzburg
Würzburg, Germany, 97080
Actively Recruiting
3
Departement of Internal Medicine, Kantonsspital Aarau
Aarau, Switzerland, 5001
Actively Recruiting
4
Kantonsspital Baden
Baden, Switzerland, 5404
Actively Recruiting
5
Endocrinology/Diabetology/Metabolism; University Hospital Basel
Basel, Switzerland, 4031
Terminated
6
St. Claraspital Basel
Basel, Switzerland, 4058
Actively Recruiting
7
Department of Rheumatology, Immunology, and Allergology, Inselspital
Bern, Switzerland, 3010
Terminated
8
Division of Gastroenterology, Spital Bülach AG
Bülach, Switzerland, 8180
Terminated
9
Kantonsspital Frauenfeld
Frauenfeld, Switzerland, 8501
Actively Recruiting
10
Geneva University Hospitals
Geneva, Switzerland, 1205
Actively Recruiting
11
Center for Primary Health Care,University of Basel, Kantonsspital Baselland
Liestal, Switzerland, 4410
Terminated
12
Internal Medicine, Kantonsspital Baselland/Liestal
Liestal, Switzerland, 4410
Actively Recruiting
13
Department of Internal Medicine, Kantonsspital Münsterlingen
Münsterlingen, Switzerland, 8596
Actively Recruiting
14
Stoffwechselzentrum, Kantonsspital Olten
Olten, Switzerland, 4600
Terminated
15
Department of Internal Medicine, Kantonsspital St. Gallen
Sankt Gallen, Switzerland, 9007
Actively Recruiting
16
Dept. of Endocrinology, Diabetology and Clinical Nutrition, University Hospital
Zurich, Switzerland, 8091
Terminated
Research Team
J
Jonas Rutishauser, Prof MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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