Actively Recruiting
Tapering Heart Failure Medication in Patients With Heart Failure With Recovered Ejection Fraction; Open Label Prospective Random Trial
Led by Chungnam National University Hospital · Updated on 2026-03-27
150
Participants Needed
2
Research Sites
142 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study start date is on Nov 27th 2024. A patient with an initial ejection fraction (EF) of less than 40%, whose follow-up shows an improvement to an EF of 50% or higher, along with the left ventricular end-diastolic diameter returning to the normal range and taking 3 more heart failure medication randomed to drug tapering group ( RAS blocker or beta blocker) or continuing medication group.
CONDITIONS
Official Title
Tapering Heart Failure Medication in Patients With Heart Failure With Recovered Ejection Fraction; Open Label Prospective Random Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Initial echocardiogram showing ejection fraction less than 40%
- Follow-up echocardiogram showing ejection fraction over 50% and normal left ventricular end-diastolic diameter index
- NT-proBNP levels meeting criteria based on kidney function (eGFR levels)
- Currently taking more than three heart failure medications, including RAS blockers, beta blockers, mineralocorticoid receptor antagonists, or SGLT2 inhibitors
You will not qualify if you...
- Under 18 years old
- Uncontrolled blood pressure over 150/90
- Coronary revascularization within the last 6 months
- Significant valve disease
- Arrhythmia requiring rate control
- Chronic kidney disease with albuminuria over 30 mg/g
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Jeonbuk national university hospital
Jeonju, Jeollabuk-do, South Korea, 54907
Actively Recruiting
2
Chungnam national university hospital
Daejeon, Republic of Korea, South Korea, 35015
Actively Recruiting
Research Team
Y
Yujin Yang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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