Actively Recruiting
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
Led by American Society of Clinical Oncology · Updated on 2026-04-02
4200
Participants Needed
174
Research Sites
667 weeks
Total Duration
On this page
Sponsors
A
American Society of Clinical Oncology
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers). \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* Results in publication or poster presentation format are posted as they become available for individual cohorts at www.tapur.org/news. The results may be accessed at any time. All results will be made available on clinicaltrials.gov at the end of the study. Indexing of available results on PubMed is in progress. \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*
CONDITIONS
Official Title
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 12 years of age or older (restrictions apply; not all therapies are available for patients under 18)
- Histologically proven locally advanced or metastatic solid tumor, multiple myeloma, or B cell non-Hodgkin lymphoma
- Cancer that is no longer benefiting from standard anti-cancer treatment or no such treatment is available or indicated
- Performance status 0-2 according to Eastern Cooperative Oncology Group (ECOG) criteria
- Acceptable organ function including: absolute neutrophil count ≥ 1.5 x 10^6/µl; hemoglobin > 9.0 g/dl; platelets > 75,000/µl; total bilirubin < 2.0 mg/dl (except Gilbert's Syndrome); AST and ALT < 2.5 x institutional upper limit of normal or < 5 x ULN if hepatic metastases present; serum creatinine ≤ 1.5 x ULN or creatinine clearance ≥ 50 mL/min/1.73 m2
- Measurable disease by physical or radiographic exam per RECIST v1.1, Lugano criteria, or International Myeloma Working Group criteria
- Genomic or immunohistochemistry test results performed in qualified laboratories confirming tumor genomic profile for targeted treatment
- Ability to understand and willingness to sign informed consent/assent
- Tumor genomic profile indicating potential benefit from single agent use of FDA-approved targeted anti-cancer drugs in this study
- Ability to swallow and tolerate oral medications if orally administered drugs are prescribed
- Women of child-bearing potential and men must agree to use adequate contraception during study and for four months after
You will not qualify if you...
- Disease that is not measurable or cannot be assessed by imaging or physical examination (e.g., elevated tumor marker only)
- Primary brain tumors or new, untreated, or progressive leptomeningeal metastases
- Untreated brain metastases or brain metastases with seizures or neurological changes within 3 months prior to registration
- Patients with previously treated brain metastases must be stable for at least 1 month after treatment and off steroids for 1 month prior to enrollment
- Known progressive brain metastases with additional eligibility criteria
- Additional exclusion criteria may apply as specified in the protocol appendix
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 174 locations
1
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Cancer Treatment Centers of America-Phoenix
Phoenix, Arizona, United States, 85338
Actively Recruiting
3
Sutter Auburn
Auburn, California, United States, 95602
Actively Recruiting
4
Sutter Alta Bates
Berkeley, California, United States, 94705
Actively Recruiting
5
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate
Los Angeles, California, United States, 90025
Actively Recruiting
6
Kaiser Permanente - Oakland Medical Center
Oakland, California, United States, 94611
Actively Recruiting
7
Sutter Palo Alto Medical Foundation: Palo Alto
Palo Alto, California, United States, 94301
Actively Recruiting
8
Kaiser Permanente - Roseville Medical Center
Roseville, California, United States, 95661
Actively Recruiting
9
Sutter Roseville
Roseville, California, United States, 95661
Actively Recruiting
10
Kaiser Permanente - Sacramento Medical Center
Sacramento, California, United States, 95814
Actively Recruiting
11
Sutter Sacramento
Sacramento, California, United States, 95816
Actively Recruiting
12
Kaiser Permanente - South San Francisco Medical Center
San Francisco, California, United States, 94080
Actively Recruiting
13
California Pacific Medical Center Research Institute
San Francisco, California, United States, 94115
Actively Recruiting
14
Kaiser Permanente - San Francisco Medical Center
San Francisco, California, United States, 94115
Actively Recruiting
15
Sutter Cancer Research Consortium
San Francisco, California, United States, 94115
Actively Recruiting
16
Kaiser Permanente - San Jose Medical Center
San Jose, California, United States, 95119
Actively Recruiting
17
Kaiser Permanente - San Leandro Medical Center
San Leandro, California, United States, 94577
Actively Recruiting
18
Sutter Sansum Clinic
Santa Barbara, California, United States, 93105
Actively Recruiting
19
Kaiser Permanente - Santa Clara Medical Center
Santa Clara, California, United States, 95051
Actively Recruiting
20
Sutter Palo Alto Medical Foundation: Santa Cruz
Santa Cruz, California, United States, 95065
Actively Recruiting
21
Sutter Palo Alto Medical Foundation: Fremont
Santa Cruz, California, United States, 994538
Actively Recruiting
22
Sutter Palo Alto Medical Foundation: Sunnyvale
Sunnyvale, California, United States, 94086
Actively Recruiting
23
Kaiser Permanente - Vallejo Medical Center
Vallejo, California, United States, 94589
Actively Recruiting
24
Kaiser Permanente - Walnut Creek Medical Center
Walnut Creek, California, United States, 94596
Actively Recruiting
25
Saint Vincent's Medical Center (SVMC)
Bridgeport, Connecticut, United States, 06606
Actively Recruiting
26
Hartford Hospital
Hartford, Connecticut, United States, 06102
Actively Recruiting
27
Midstate Medical Center (MSMC)
Meriden, Connecticut, United States, 06451
Actively Recruiting
28
The Hospital of Central Connecticut (HOCC) Cancer Center
New Britain, Connecticut, United States, 06053
Actively Recruiting
29
William W. Backus Hospital
Norwich, Connecticut, United States, 06360
Actively Recruiting
30
Charlotte Hungerford
Torrington, Connecticut, United States, 06790
Actively Recruiting
31
Windham Hospital (WH)
Willimantic, Connecticut, United States, 06226
Actively Recruiting
32
Florida Cancer Specialists North / Sarah Cannon Research Institute
Altamonte Springs, Florida, United States, 32701
Active, Not Recruiting
33
University of Miami/Sylvester Cancer Institute - Aventura
Aventura, Florida, United States, 33180
Actively Recruiting
34
Florida Cancer Specialists South / Sarah Cannon Research Institute
Bonita Springs, Florida, United States, 34135
Active, Not Recruiting
35
Florida Cancer Specialists South / Sarah Cannon Research Institute
Bradenton, Florida, United States, 34211
Active, Not Recruiting
36
Florida Cancer Specialists North / Sarah Cannon Research Institute
Brandon, Florida, United States, 33511
Active, Not Recruiting
37
Florida Cancer Specialists South / Sarah Cannon Research Institute
Cape Coral, Florida, United States, 33909
Active, Not Recruiting
38
Florida Cancer Specialists North / Sarah Cannon Research Institute
Clearwater, Florida, United States, 33761
Active, Not Recruiting
39
University of Miami/Sylvester Cancer Institute - Lennar
Coral Gables, Florida, United States, 33146
Actively Recruiting
40
University of Miami/Sylvester Cancer Institute - Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Actively Recruiting
41
Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
42
Florida Cancer Specialists South / Sarah Cannon Research Institute
Fort Myers, Florida, United States, 33901
Active, Not Recruiting
43
Florida Cancer Specialists South / Sarah Cannon Research Institute
Fort Myers, Florida, United States, 33905
Active, Not Recruiting
44
Florida Cancer Specialists South / Sarah Cannon Research Institute
Fort Myers, Florida, United States, 33908
Active, Not Recruiting
45
Florida Cancer Specialists North / Sarah Cannon Research Institute
Gainesville, Florida, United States, 32605
Active, Not Recruiting
46
University of Florida Health
Gainesville, Florida, United States, 32610
Actively Recruiting
47
Florida Cancer Specialists North / Sarah Cannon Research Institute
Largo, Florida, United States, 33770
Active, Not Recruiting
48
Florida Cancer Specialists North / Sarah Cannon Research Institute
Lecanto, Florida, United States, 34461
Active, Not Recruiting
49
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
50
University of Miami/Sylvester Cancer Institute - Alex's Place
Miami, Florida, United States, 33136
Actively Recruiting
51
University of Miami/Sylvester Cancer Institute - Griffin Cancer Research Building
Miami, Florida, United States, 33136
Actively Recruiting
52
University of Miami/Sylvester Cancer Institute - Kendall
Miami, Florida, United States, 33176
Actively Recruiting
53
University of Miami/Sylvester Cancer Institute - Sole Mia
Miami, Florida, United States, 33181
Actively Recruiting
54
Florida Cancer Specialists South / Sarah Cannon Research Institute
Naples, Florida, United States, 34102
Active, Not Recruiting
55
Florida Cancer Specialists North / Sarah Cannon Research Institute
Ocala, Florida, United States, 34474
Active, Not Recruiting
56
Florida Cancer Specialists North / Sarah Cannon Research Institute
Orange City, Florida, United States, 32763
Active, Not Recruiting
57
Florida Cancer Specialists North / Sarah Cannon Research Institute
Orlando, Florida, United States, 32806
Active, Not Recruiting
58
University of Miami/Sylvester Cancer Institute - Plantation
Plantation, Florida, United States, 33324
Actively Recruiting
59
Florida Cancer Specialists South / Sarah Cannon Research Institute
Port Charlotte, Florida, United States, 33980
Active, Not Recruiting
60
Florida Cancer Specialists South / Sarah Cannon Research Institute
Sarasota, Florida, United States, 34232
Active, Not Recruiting
61
Florida Cancer Specialists South / Sarah Cannon Research Institute
Sarasota, Florida, United States, 34236
Active, Not Recruiting
62
Florida Cancer Specialists North / Sarah Cannon Research Institute
St. Petersburg, Florida, United States, 33701
Active, Not Recruiting
63
Florida Cancer Specialists North / Sarah Cannon Research Institute
Tampa, Florida, United States, 33607
Active, Not Recruiting
64
Florida Cancer Specialists North / Sarah Cannon Research Institute
Tavares, Florida, United States, 32778
Active, Not Recruiting
65
Florida Cancer Specialists North / Sarah Cannon Research Institute
The Villages, Florida, United States, 32159
Active, Not Recruiting
66
Florida Cancer Specialists North / Sarah Cannon Research Institute
Trinity, Florida, United States, 34655
Active, Not Recruiting
67
Florida Cancer Specialists South / Sarah Cannon Research Institute
Venice, Florida, United States, 34285
Active, Not Recruiting
68
Florida Cancer Specialists South / Sarah Cannon Research Institute
Venice, Florida, United States, 34292
Active, Not Recruiting
69
Florida Cancer Specialists North / Sarah Cannon Research Institute
Winter Park, Florida, United States, 32789
Active, Not Recruiting
70
Cancer Treatment Centers of America - Atlanta
Atlanta, Georgia, United States, 30265
Actively Recruiting
71
Emory University Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
72
Gynecologic Oncology and Surgical Specialists at the Lewis Cancer & Research Pavilion
Savannah, Georgia, United States, 31405
Actively Recruiting
73
Lewis Cancer & Research Pavilion at the Melanoma, Skin Cancer & Sarcoma Institute
Savannah, Georgia, United States, 31405
Actively Recruiting
74
Lewis Cancer & Research Pavilion
Savannah, Georgia, United States, 31405
Actively Recruiting
75
Summit Cancer Care
Savannah, Georgia, United States, 31405
Actively Recruiting
76
The Queen's Medical Center - POB I
Honolulu, Hawaii, United States, 96813
Actively Recruiting
77
The Queen's Medical Center - Punchbowl
Honolulu, Hawaii, United States, 96813
Actively Recruiting
78
The Queen's Medical Center - Kuakini
Honolulu, Hawaii, United States, 96817
Actively Recruiting
79
The Queen's Medical Center - West Oahu
‘Ewa Beach, Hawaii, United States, 96706
Actively Recruiting
80
Cancer Treatment Centers of America-Chicago
Chicago, Illinois, United States, 60099
Actively Recruiting
81
Community Health Network (The University of Texas MD Anderson Cancer Center)
Indianapolis, Indiana, United States, 46250
Actively Recruiting
82
Harold Alfond Center for Cancer Care
Augusta, Maine, United States, 04330
Actively Recruiting
83
Jackson Laboratory - Maine Cancer Genomics Initiative
Augusta, Maine, United States, 04330
Actively Recruiting
84
Waldo County General Hospital
Belfast, Maine, United States, 04915
Actively Recruiting
85
SMHC Cancer Care and Blood Disorders -Biddeford
Biddeford, Maine, United States, 04005
Actively Recruiting
86
Northern Light Cancer Care
Brewer, Maine, United States, 04412
Actively Recruiting
87
Raish Peavey Haskell Children's Cancer and Treatment Center
Brewer, Maine, United States, 04412
Actively Recruiting
88
MaineHealth Cancer Care -Brunswick
Brunswick, Maine, United States, 04011
Actively Recruiting
89
New England Cancer Specialist
Kennebunk, Maine, United States, 04043
Actively Recruiting
90
York Hopsital Oncology & Infusion Care in Kittery
Kittery, Maine, United States, 03904
Actively Recruiting
91
Stephens Memorial Hospital
Norway, Maine, United States, 04268
Actively Recruiting
92
Penobscot Bay Medical Center
Rockport, Maine, United States, 04856
Actively Recruiting
93
SMHC Cancer Care and Blood Disorders -Sandford
Sanford, Maine, United States, 04073
Actively Recruiting
94
Maine Children's Cancer Program
Scarborough, Maine, United States, 04074
Actively Recruiting
95
Maine Medical Partner's Women's Health
Scarborough, Maine, United States, 04074
Actively Recruiting
96
New England Cancer Specialist
Scarborough, Maine, United States, 04074
Actively Recruiting
97
MaineHealth Cancer Care -South Portland
South Portland, Maine, United States, 04106
Actively Recruiting
98
New England Cancer Specialist
Topsham, Maine, United States, 04086
Actively Recruiting
99
York Hospital Oncology & Infusion Care in Wells
Wells, Maine, United States, 04090
Actively Recruiting
100
York Hospital Oncology & Infusion Care in York
York Village, Maine, United States, 03909
Actively Recruiting
101
Trinity Health Ann Arbor Hospital
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
102
University of Michigan
Ann Arbor, Michigan, United States, 48109
Active, Not Recruiting
103
Henry Ford Health Saint John Hospital
Detroit, Michigan, United States, 48236
Actively Recruiting
104
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Actively Recruiting
105
Cancer Research Consortium of West Michigan
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
106
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, United States, 48912
Actively Recruiting
107
Trinity Health Livonia Hospital
Livonia, Michigan, United States, 48154
Actively Recruiting
108
Trinity Health Oakland Hospital
Pontiac, Michigan, United States, 48341
Actively Recruiting
109
MyMichigan Medical Center Saginaw
Saginaw, Michigan, United States, 48601
Actively Recruiting
110
Michigan Cancer Research Consortium
Traverse City, Michigan, United States, 48341
Actively Recruiting
111
Henry Ford Health Warren Hospital
Warren, Michigan, United States, 48093
Actively Recruiting
112
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
113
NH Oncology - Hematology, PA
Concord, New Hampshire, United States, 03103
Actively Recruiting
114
Solinsky Center for Cancer Care
Manchester, New Hampshire, United States, 03103
Actively Recruiting
115
New England Cancer Specialist
Portsmouth, New Hampshire, United States, 03801
Actively Recruiting
116
Lovelace Medical Center - Saint Joseph Square
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
117
Presbyterian Kaseman Hospital
Albuquerque, New Mexico, United States, 87110
Actively Recruiting
118
The University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
119
Memorial Medical Center
Las Cruces, New Mexico, United States, 88011
Actively Recruiting
120
Presbyterian Rust Medical Center
Rio Rancho, New Mexico, United States, 87124
Actively Recruiting
121
Northwell Health Monter Cancer Center
Lake Success, New York, United States, 11042
Actively Recruiting
122
Northern Westchester Hospital
Mount Kisco, New York, United States, 10549
Actively Recruiting
123
Cohen Children's Medical Center
New Hyde Park, New York, United States, 11040
Actively Recruiting
124
Manhattan Eye, Ear, and Throat Hospital
New York, New York, United States, 10065
Actively Recruiting
125
Staten Island University Hospital
New York, New York, United States, 10305
Actively Recruiting
126
Queens Cancer Center
Rego Park, New York, United States, 11374
Actively Recruiting
127
Phelps Hospital
Sleepy Hollow, New York, United States, 10591
Actively Recruiting
128
Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
129
Atrium Health's Levine Cancer Institute
Charlotte, North Carolina, United States, 28277
Actively Recruiting
130
Sanford Health- Bismarck
Bismarck, North Dakota, United States, 58501
Actively Recruiting
131
Sanford Health- Fargo
Fargo, North Dakota, United States, 58122
Actively Recruiting
132
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
133
Kettering Health
Kettering, Ohio, United States, 45429
Actively Recruiting
134
West Chester Hospital
West Chester, Ohio, United States, 45069
Actively Recruiting
135
Providence Health & Services
Portland, Oregon, United States, 97213
Actively Recruiting
136
Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
137
Lehigh Valley Hospital- Muhlenberg
Bethlehem, Pennsylvania, United States, 18017
Actively Recruiting
138
Pocono Medical Center
East Stroudsburg, Pennsylvania, United States, 18301
Actively Recruiting
139
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, United States, 18201
Actively Recruiting
140
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Actively Recruiting
141
SC Cancer Specialists at St. Joseph's/Candler Bluffton
Bluffton, South Carolina, United States, 29910
Actively Recruiting
142
St. Joseph's/Candler Smith
Bluffton, South Carolina, United States, 29910
Actively Recruiting
143
Summit Cancer Care at St. Josph's/Candler Bluffton
Bluffton, South Carolina, United States, 29910
Actively Recruiting
144
South Carolina Cancer Specialists
Hilton Head Island, South Carolina, United States, 29926
Actively Recruiting
145
Sanford Cancer Center Oncology Clinic and Pharmacy
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
146
Tennessee Oncology - Nashville / Sarah Cannon Research Institute
Nashville, Tennessee, United States, 37203
Actively Recruiting
147
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
148
Cedar City Hospital, SW Cancer Clinic, Sandra Maxwell Cancer Center
Cedar City, Utah, United States, 84720
Actively Recruiting
149
Intermountain Healthcare
Salt Lake City, Utah, United States, 84107
Actively Recruiting
150
Dixie Regional Medical Center-River Road Campus
St. George, Utah, United States, 84770
Actively Recruiting
151
Inova Schar Cancer Institute
Fairfax, Virginia, United States, 22042
Actively Recruiting
152
Northwest Medical Specialties
Bonney Lake, Washington, United States, 98391
Actively Recruiting
153
Northwest Medical Specialties
Federal Way, Washington, United States, 98003
Actively Recruiting
154
Northwest Medical Specialties
Gig Harbor, Washington, United States, 98332
Actively Recruiting
155
Northwest Medical Specialties
Olympia, Washington, United States, 98502
Actively Recruiting
156
Northwest Medical Specialties
Puyallup, Washington, United States, 98373
Actively Recruiting
157
Swedish Cancer Institute
Seattle, Washington, United States, 98104
Actively Recruiting
158
Northwest Medical Specialties
Tacoma, Washington, United States, 98405
Actively Recruiting
159
Aurora Cancer Care - Burlington
Burlington, Wisconsin, United States, 53105
Actively Recruiting
160
Aurora Health Care - Germantown Health Center
Germantown, Wisconsin, United States, 53022
Actively Recruiting
161
Aurora Cancer Care - Grafton
Grafton, Wisconsin, United States, 53024
Actively Recruiting
162
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311
Actively Recruiting
163
Aurora Cancer Care - Kenosha South
Kenosha, Wisconsin, United States, 53142
Actively Recruiting
164
Aurora Bay Area Medical Center
Marinette, Wisconsin, United States, 54143
Actively Recruiting
165
Aurora Cancer Care Milwaukee
Milwaukee, Wisconsin, United States, 53209
Actively Recruiting
166
Aurora St. Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Actively Recruiting
167
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53223
Actively Recruiting
168
Aurora West Allis Medical Center
Milwaukee, Wisconsin, United States, 53227
Actively Recruiting
169
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Actively Recruiting
170
Aurora Cancer Care - Racine
Racine, Wisconsin, United States, 53406
Actively Recruiting
171
Vince Lombardi Cancer Center
Sheboygan, Wisconsin, United States, 53081
Actively Recruiting
172
Aurora Medical Center in Summit
Summit, Wisconsin, United States, 53066
Actively Recruiting
173
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers, Wisconsin, United States, 54241
Actively Recruiting
174
Aurora Cancer Care - Milwaukee West
Wauwatosa, Wisconsin, United States, 53226
Actively Recruiting
Research Team
P
Pam Mangat, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
15
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