What is this study trying to find out about advanced cancer?

This study is evaluating FDA-approved targeted therapies for patients with advanced cancers that have specific genetic changes. Researchers want to learn how these drugs work in real-world practice and gather information to guide future cancer treatment studies. The study is sponsored by the American Society of Clinical Oncology.

Who may be eligible for this advanced cancer clinical trial?

People aged 12 years or older with locally advanced or metastatic solid tumors, multiple myeloma, or B cell non-Hodgkin lymphoma may be eligible. Participants should have cancer that is not benefiting from standard treatments and measurable disease. Both males and females can join. Please review eligibility criteria for more details.

Is there any cost to participate in this advanced cancer clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. However, personal travel and related expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Phase 2

Age: 12Years +

All Genders

ID02693535

Targeted Agent and Profiling Utilization Registry (TAPUR) Study

Led by American Society of Clinical Oncology · Updated on 2026-05-29

4200

Participants Needed

181

Research Sites

52 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating targeted therapies approved by the Food and Drug Administration (FDA) for patients with advanced cancers that have specific genetic changes. This study, called the Targeted Agent and Profiling Utilization Registry (TAPUR) Study, aims to understand how safely and effectively these targeted drugs work when prescribed in real-world settings for cancers with actionable genomic variants. The study also collects data on molecular testing choices and helps generate ideas for future clinical trials. Participants receive one of several FDA-approved targeted anticancer drugs, chosen based on specific genetic features of their tumors. These drugs include palbociclib, sunitinib, temsirolimus, trastuzumab with pertuzumab, vemurafenib with cobimetinib, regorafenib, olaparib, nivolumab with ipilimumab, abemaciclib, talazoparib, atezolizumab with talazoparib, tucatinib with trastuzumab, futibatinib, dabrafenib with trametinib, and fam-trastuzumab deruxtecan-nxki. Each treatment follows the approved dosing schedule and duration. Different genetic alterations qualify patients for different drugs, and the study covers a wide range of tumor types, including advanced solid tumors, multiple myeloma, and non-Hodgkin lymphoma. During the study, participants undergo regular assessments including physical exams and imaging tests to measure tumor response using standard criteria. The main outcome measured is the percentage of patients with tumor shrinkage or stable disease after 16 weeks of treatment. Researchers also monitor overall survival for up to three years. Safety and organ function are closely tracked through laboratory tests. Participants must provide informed consent and meet specific eligibility criteria, including measurable disease and acceptable organ function. The study does not use random assignment, and results are shared publicly as they become available and at study completion.

CONDITIONS

Brief Title

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Who Can Participate

Age: 12Years +

All Genders

Eligibility Criteria

You may qualify if you...

12 years of age or older (restrictions apply for patients under 18)
Diagnosed with histologically-proven locally advanced or metastatic solid tumor, multiple myeloma, or B cell non-Hodgkin lymphoma
No longer benefiting from standard anti-cancer treatments or no such treatment is available or indicated
Performance status of 0 to 2 as per ECOG criteria
Acceptable organ function including neutrophil count ≥ 1.5 x 10^6/µl, hemoglobin > 9.0 g/dl, platelets > 75,000/µl
Total bilirubin < 2.0 mg/dl except for Gilbert's Syndrome
AST and ALT less than 2.5 times institutional upper limit of normal (or less than 5 times if liver metastases are present)
Serum creatinine ≤ 1.5 times upper limit of normal or creatinine clearance ≥ 50 mL/min/1.73 m²
Disease measurable by physical or radiographic exam as defined by RECIST v1.1, Lugano criteria, or International Myeloma Working Group criteria
Genomic or immunohistochemistry test results available from approved laboratories
Ability to understand and willingly sign informed consent or assent
Tumor genomic profile matching one of the FDA-approved targeted drugs in the study
Ability to swallow oral medications and no known malabsorption syndrome (if applicable)
Agreement to use adequate contraception for women of child-bearing potential and men during and for four months after study participation

You will not qualify if you...

Disease not measurable or not assessable by imaging or physical exam (e.g., elevated tumor marker only)
Primary brain tumors or new, untreated, or progressive leptomeningeal metastases
Untreated or unstable brain metastases; patients with previously treated brain metastases must be clinically stable for at least one month and off steroids for one month
Known progressive brain metastases with additional eligibility restrictions
Other exclusion criteria may apply as detailed in the protocol appendix

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 screening and enrollment visit

Treatment

Duration - Duration per label for each drug

Participants receive FDA-approved targeted anticancer drugs matched to their tumor's genomic profile. Dosage, frequency, and duration follow approved labels.

Visits as required per treatment label

Trial Site Locations

Total: 181 locations

University of Alabama at Birmingham Comprehensive Cancer Center

Birmingham, Alabama, United States, 35294

Actively Recruiting

Cancer Treatment Centers of America-Phoenix

Phoenix, Arizona, United States, 85338

Actively Recruiting

Sutter Auburn

Auburn, California, United States, 95602

Actively Recruiting

Sutter Alta Bates

Berkeley, California, United States, 94705

Actively Recruiting

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate

Los Angeles, California, United States, 90025

Actively Recruiting

Kaiser Permanente - Oakland Medical Center

Oakland, California, United States, 94611

Actively Recruiting

Sutter Palo Alto Medical Foundation: Palo Alto

Palo Alto, California, United States, 94301

Actively Recruiting

Kaiser Permanente - Roseville Medical Center

Roseville, California, United States, 95661

Actively Recruiting

Sutter Roseville

Roseville, California, United States, 95661

Actively Recruiting

Kaiser Permanente - Sacramento Medical Center

Sacramento, California, United States, 95814

Actively Recruiting

Sutter Sacramento

Sacramento, California, United States, 95816

Actively Recruiting

Kaiser Permanente - South San Francisco Medical Center

San Francisco, California, United States, 94080

Actively Recruiting

California Pacific Medical Center Research Institute

San Francisco, California, United States, 94115

Actively Recruiting

Kaiser Permanente - San Francisco Medical Center

San Francisco, California, United States, 94115

Actively Recruiting

Sutter Cancer Research Consortium

San Francisco, California, United States, 94115

Actively Recruiting

Kaiser Permanente - San Jose Medical Center

San Jose, California, United States, 95119

Actively Recruiting

Kaiser Permanente - San Leandro Medical Center

San Leandro, California, United States, 94577

Actively Recruiting

Sutter Sansum Clinic

Santa Barbara, California, United States, 93105

Actively Recruiting

Kaiser Permanente - Santa Clara Medical Center

Santa Clara, California, United States, 95051

Actively Recruiting

Sutter Palo Alto Medical Foundation: Santa Cruz

Santa Cruz, California, United States, 95065

Actively Recruiting

Sutter Palo Alto Medical Foundation: Fremont

Santa Cruz, California, United States, 994538

Actively Recruiting

Sutter Palo Alto Medical Foundation: Sunnyvale

Sunnyvale, California, United States, 94086

Actively Recruiting

Kaiser Permanente - Vallejo Medical Center

Vallejo, California, United States, 94589

Actively Recruiting

Kaiser Permanente - Walnut Creek Medical Center

Walnut Creek, California, United States, 94596

Actively Recruiting

Saint Vincent's Medical Center (SVMC)

Bridgeport, Connecticut, United States, 06606

Actively Recruiting

Hartford Hospital

Hartford, Connecticut, United States, 06102

Actively Recruiting

Midstate Medical Center (MSMC)

Meriden, Connecticut, United States, 06451

Actively Recruiting

The Hospital of Central Connecticut (HOCC) Cancer Center

New Britain, Connecticut, United States, 06053

Actively Recruiting

William W. Backus Hospital

Norwich, Connecticut, United States, 06360

Actively Recruiting

Charlotte Hungerford

Torrington, Connecticut, United States, 06790

Actively Recruiting

Windham Hospital (WH)

Willimantic, Connecticut, United States, 06226

Actively Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Altamonte Springs, Florida, United States, 32701

Active, Not Recruiting

University of Miami/Sylvester Cancer Institute - Aventura

Aventura, Florida, United States, 33180

Actively Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Bonita Springs, Florida, United States, 34135

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Bradenton, Florida, United States, 34211

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Brandon, Florida, United States, 33511

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Cape Coral, Florida, United States, 33909

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Clearwater, Florida, United States, 33761

Active, Not Recruiting

University of Miami/Sylvester Cancer Institute - Lennar

Coral Gables, Florida, United States, 33146

Actively Recruiting

University of Miami/Sylvester Cancer Institute - Deerfield Beach

Deerfield Beach, Florida, United States, 33442

Actively Recruiting

Holy Cross Hospital

Fort Lauderdale, Florida, United States, 33308

Actively Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, United States, 33901

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, United States, 33905

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Fort Myers, Florida, United States, 33908

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Gainesville, Florida, United States, 32605

Active, Not Recruiting

University of Florida Health

Gainesville, Florida, United States, 32610

Actively Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Largo, Florida, United States, 33770

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Lecanto, Florida, United States, 34461

Active, Not Recruiting

University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, United States, 33136

Actively Recruiting

University of Miami/Sylvester Cancer Institute - Alex's Place

Miami, Florida, United States, 33136

Actively Recruiting

University of Miami/Sylvester Cancer Institute - Griffin Cancer Research Building

Miami, Florida, United States, 33136

Actively Recruiting

University of Miami/Sylvester Cancer Institute - Kendall

Miami, Florida, United States, 33176

Actively Recruiting

University of Miami/Sylvester Cancer Institute - Sole Mia

Miami, Florida, United States, 33181

Actively Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Naples, Florida, United States, 34102

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Ocala, Florida, United States, 34474

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Orange City, Florida, United States, 32763

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Orlando, Florida, United States, 32806

Active, Not Recruiting

University of Miami/Sylvester Cancer Institute - Plantation

Plantation, Florida, United States, 33324

Actively Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Port Charlotte, Florida, United States, 33980

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Sarasota, Florida, United States, 34232

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Sarasota, Florida, United States, 34236

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

St. Petersburg, Florida, United States, 33701

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Tampa, Florida, United States, 33607

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Tavares, Florida, United States, 32778

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

The Villages, Florida, United States, 32159

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Trinity, Florida, United States, 34655

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Venice, Florida, United States, 34285

Active, Not Recruiting

Florida Cancer Specialists South / Sarah Cannon Research Institute

Venice, Florida, United States, 34292

Active, Not Recruiting

Florida Cancer Specialists North / Sarah Cannon Research Institute

Winter Park, Florida, United States, 32789

Active, Not Recruiting

Cancer Treatment Centers of America - Atlanta

Atlanta, Georgia, United States, 30265

Actively Recruiting

Emory University Winship Cancer Institute

Atlanta, Georgia, United States, 30322

Actively Recruiting

Gynecologic Oncology and Surgical Specialists at the Lewis Cancer & Research Pavilion

Savannah, Georgia, United States, 31405

Actively Recruiting

Lewis Cancer & Research Pavilion at the Melanoma, Skin Cancer & Sarcoma Institute

Savannah, Georgia, United States, 31405

Actively Recruiting

Lewis Cancer & Research Pavilion

Savannah, Georgia, United States, 31405

Actively Recruiting

Summit Cancer Care

Savannah, Georgia, United States, 31405

Actively Recruiting

The Queen's Medical Center - POB I

Honolulu, Hawaii, United States, 96813

Actively Recruiting

The Queen's Medical Center - Punchbowl

Honolulu, Hawaii, United States, 96813

Actively Recruiting

The Queen's Medical Center - Kuakini

Honolulu, Hawaii, United States, 96817

Actively Recruiting

The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, United States, 96706

Actively Recruiting

Cancer Treatment Centers of America-Chicago

Chicago, Illinois, United States, 60099

Actively Recruiting

Community Health Network (The University of Texas MD Anderson Cancer Center)

Indianapolis, Indiana, United States, 46250

Actively Recruiting

Harold Alfond Center for Cancer Care

Augusta, Maine, United States, 04330

Actively Recruiting

Jackson Laboratory - Maine Cancer Genomics Initiative

Augusta, Maine, United States, 04330

Actively Recruiting

Waldo County General Hospital

Belfast, Maine, United States, 04915

Actively Recruiting

SMHC Cancer Care and Blood Disorders -Biddeford

Biddeford, Maine, United States, 04005

Actively Recruiting

Northern Light Cancer Care

Brewer, Maine, United States, 04412

Actively Recruiting

Raish Peavey Haskell Children's Cancer and Treatment Center

Brewer, Maine, United States, 04412

Actively Recruiting

MaineHealth Cancer Care -Brunswick

Brunswick, Maine, United States, 04011

Actively Recruiting

New England Cancer Specialist

Kennebunk, Maine, United States, 04043

Actively Recruiting

York Hopsital Oncology & Infusion Care in Kittery

Kittery, Maine, United States, 03904

Actively Recruiting

Stephens Memorial Hospital

Norway, Maine, United States, 04268

Actively Recruiting

Penobscot Bay Medical Center

Rockport, Maine, United States, 04856

Actively Recruiting

SMHC Cancer Care and Blood Disorders -Sandford

Sanford, Maine, United States, 04073

Actively Recruiting

Maine Children's Cancer Program

Scarborough, Maine, United States, 04074

Actively Recruiting

Maine Medical Partner's Women's Health

Scarborough, Maine, United States, 04074

Actively Recruiting

New England Cancer Specialist

Scarborough, Maine, United States, 04074

Actively Recruiting

MaineHealth Cancer Care -South Portland

South Portland, Maine, United States, 04106

Actively Recruiting

New England Cancer Specialist

Topsham, Maine, United States, 04086

Actively Recruiting

York Hospital Oncology & Infusion Care in Wells

Wells, Maine, United States, 04090

Actively Recruiting

100

York Hospital Oncology & Infusion Care in York

York Village, Maine, United States, 03909

Actively Recruiting

101

Trinity Health Ann Arbor Hospital

Ann Arbor, Michigan, United States, 48106

Actively Recruiting

102

University of Michigan

Ann Arbor, Michigan, United States, 48109

Active, Not Recruiting

103

Henry Ford Health Saint John Hospital

Detroit, Michigan, United States, 48236

Actively Recruiting

104

Genesys Hurley Cancer Institute

Flint, Michigan, United States, 48503

Actively Recruiting

105

Cancer Research Consortium of West Michigan

Grand Rapids, Michigan, United States, 49503

Actively Recruiting

106

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, United States, 48912

Actively Recruiting

107

Trinity Health Livonia Hospital

Livonia, Michigan, United States, 48154

Actively Recruiting

108

Trinity Health Oakland Hospital

Pontiac, Michigan, United States, 48341

Actively Recruiting

109

MyMichigan Medical Center Saginaw

Saginaw, Michigan, United States, 48601

Actively Recruiting

110

Michigan Cancer Research Consortium

Traverse City, Michigan, United States, 48341

Actively Recruiting

111

Henry Ford Health Warren Hospital

Warren, Michigan, United States, 48093

Actively Recruiting

112

University of Nebraska Medical Center

Omaha, Nebraska, United States, 68198

Actively Recruiting

113

NH Oncology - Hematology, PA

Concord, New Hampshire, United States, 03103

Actively Recruiting

114

Solinsky Center for Cancer Care

Manchester, New Hampshire, United States, 03103

Actively Recruiting

115

New England Cancer Specialist

Portsmouth, New Hampshire, United States, 03801

Actively Recruiting

116

Lovelace Medical Center - Saint Joseph Square

Albuquerque, New Mexico, United States, 87102

Actively Recruiting

117

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, United States, 87110

Actively Recruiting

118

The University of New Mexico Comprehensive Cancer Center

Albuquerque, New Mexico, United States, 87131

Actively Recruiting

119

Memorial Medical Center

Las Cruces, New Mexico, United States, 88011

Actively Recruiting

120

Presbyterian Rust Medical Center

Rio Rancho, New Mexico, United States, 87124

Actively Recruiting

121

Northwell Health Monter Cancer Center

Lake Success, New York, United States, 11042

Actively Recruiting

122

Northern Westchester Hospital

Mount Kisco, New York, United States, 10549

Actively Recruiting

123

Cohen Children's Medical Center

New Hyde Park, New York, United States, 11040

Actively Recruiting

124

Manhattan Eye, Ear, and Throat Hospital

New York, New York, United States, 10065

Actively Recruiting

125

Staten Island University Hospital

New York, New York, United States, 10305

Actively Recruiting

126

Queens Cancer Center

Rego Park, New York, United States, 11374

Actively Recruiting

127

Phelps Hospital

Sleepy Hollow, New York, United States, 10591

Actively Recruiting

128

Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States, 27599

Actively Recruiting

129

Atrium Health's Levine Cancer Institute

Charlotte, North Carolina, United States, 28277

Actively Recruiting

130

Sanford Health- Bismarck

Bismarck, North Dakota, United States, 58501

Actively Recruiting

131

Sanford Health- Fargo

Fargo, North Dakota, United States, 58122

Actively Recruiting

132

University of Cincinnati Medical Center

Cincinnati, Ohio, United States, 45219

Actively Recruiting

133

Kettering Health

Kettering, Ohio, United States, 45429

Actively Recruiting

134

West Chester Hospital

West Chester, Ohio, United States, 45069

Actively Recruiting

135

Providence Health & Services

Portland, Oregon, United States, 97213

Actively Recruiting

136

Lehigh Valley Hospital - Cedar Crest

Allentown, Pennsylvania, United States, 18103

Actively Recruiting

137

Lehigh Valley Hospital- Muhlenberg

Bethlehem, Pennsylvania, United States, 18017

Actively Recruiting

138

Pocono Medical Center

East Stroudsburg, Pennsylvania, United States, 18301

Actively Recruiting

139

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, United States, 18201

Actively Recruiting

140

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States, 19111

Actively Recruiting

141

SC Cancer Specialists at St. Joseph's/Candler Bluffton

Bluffton, South Carolina, United States, 29910

Actively Recruiting

142

St. Joseph's/Candler Smith

Bluffton, South Carolina, United States, 29910

Actively Recruiting

143

Summit Cancer Care at St. Josph's/Candler Bluffton

Bluffton, South Carolina, United States, 29910

Actively Recruiting

144

South Carolina Cancer Specialists

Hilton Head Island, South Carolina, United States, 29926

Actively Recruiting

145

Sanford Cancer Center Oncology Clinic and Pharmacy

Sioux Falls, South Dakota, United States, 57104

Actively Recruiting

146

Tennessee Oncology - Nashville / Sarah Cannon Research Institute

Nashville, Tennessee, United States, 37203

Actively Recruiting

147

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

148

Cedar City Hospital, SW Cancer Clinic, Sandra Maxwell Cancer Center

Cedar City, Utah, United States, 84720

Actively Recruiting

149

Intermountain Healthcare

Salt Lake City, Utah, United States, 84107

Actively Recruiting

150

Dixie Regional Medical Center-River Road Campus

St. George, Utah, United States, 84770

Actively Recruiting

151

Inova Schar Cancer Institute

Fairfax, Virginia, United States, 22042

Actively Recruiting

152

Northwest Medical Specialties

Bonney Lake, Washington, United States, 98391

Actively Recruiting

153

Northwest Medical Specialties

Federal Way, Washington, United States, 98003

Actively Recruiting

154

Northwest Medical Specialties

Gig Harbor, Washington, United States, 98332

Actively Recruiting

155

Northwest Medical Specialties

Olympia, Washington, United States, 98502

Actively Recruiting

156

Northwest Medical Specialties

Puyallup, Washington, United States, 98373

Actively Recruiting

157

Swedish Cancer Institute

Seattle, Washington, United States, 98104

Actively Recruiting

158

Northwest Medical Specialties

Tacoma, Washington, United States, 98405

Actively Recruiting

159

Aurora Cancer Care - Burlington

Burlington, Wisconsin, United States, 53105

Actively Recruiting

160

Aurora Health Care - Germantown Health Center

Germantown, Wisconsin, United States, 53022

Actively Recruiting

161

Aurora Cancer Care - Grafton

Grafton, Wisconsin, United States, 53024

Actively Recruiting

162

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States, 54311

Actively Recruiting

163

Aurora Cancer Care - Kenosha South

Kenosha, Wisconsin, United States, 53142

Actively Recruiting

164

Aurora Bay Area Medical Center

Marinette, Wisconsin, United States, 54143

Actively Recruiting

165

Aurora Cancer Care Milwaukee

Milwaukee, Wisconsin, United States, 53209

Actively Recruiting

166

Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, United States, 53215

Actively Recruiting

167

Aurora Sinai Medical Center

Milwaukee, Wisconsin, United States, 53223

Actively Recruiting

168

Aurora West Allis Medical Center

Milwaukee, Wisconsin, United States, 53227

Actively Recruiting

169

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, United States, 54904

Actively Recruiting

170

Aurora Cancer Care - Racine

Racine, Wisconsin, United States, 53406

Actively Recruiting

171

Vince Lombardi Cancer Center

Sheboygan, Wisconsin, United States, 53081

Actively Recruiting

172

Aurora Medical Center in Summit

Summit, Wisconsin, United States, 53066

Actively Recruiting

173

Vince Lombardi Cancer Clinic - Two Rivers

Two Rivers, Wisconsin, United States, 54241

Actively Recruiting

174

Aurora Cancer Care - Milwaukee West

Wauwatosa, Wisconsin, United States, 53226

Actively Recruiting

175

PanOncology Trials

Cayey, Puerto Rico, 00737

Actively Recruiting

176

PanOncology Trials

Dorado, Puerto Rico, 00646

Actively Recruiting

177

PanOncology Trials

Manati, Puerto Rico, 00674

Actively Recruiting

178

PanOncology Trials

Mayagüez, Puerto Rico, 00680

Actively Recruiting

179

PanOncology Trials

Ponce, Puerto Rico, 00730

Actively Recruiting

180

PanOncology Trials

San Juan, Puerto Rico, 00909

Actively Recruiting

181

PanOncology Trials

San Juan, Puerto Rico, 00935

Actively Recruiting

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Research Team

Pam Mangat, MS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

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Frequently Asked Questions

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Published Research Related To This Trial

Nivolumab Plus Ipilimumab in Patients With Solid Tumors With High Tumor Mutation Burden: Results From the Targeted Agent and Profiling Utilization Registry Study.

Erin F Cobain, Michael Rothe, Elizabeth Garrett-Mayer...

https://pubmed.ncbi.nlm.nih.gov/42060861

Temsirolimus in Patients With Solid Tumors With PIK3CA Mutations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Evan Pisick, Michael Rothe, Elizabeth Garrett-Mayer...

https://pubmed.ncbi.nlm.nih.gov/42018965

Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Daniel R Carrizosa, Michael Rothe, Pam K Mangat...

https://pubmed.ncbi.nlm.nih.gov/41538762

Olaparib in Patients With Solid Tumors With BRCA1/2 Alterations: Results From The Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Tareq Al Baghdadi, Michael Rothe, Pam K Mangat...

https://pubmed.ncbi.nlm.nih.gov/41100773

Prevalence of targetable genomic alterations among a diverse population participating in the ASCO TAPUR Study.

Pam K Mangat, M Kelsey Kirkwood, Dominique C Hinshaw...

https://pubmed.ncbi.nlm.nih.gov/40610648

Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

Francis P Worden, Evan Pisick, Michael Rothe...

https://pubmed.ncbi.nlm.nih.gov/39413339

Palbociclib in Patients With Soft Tissue Sarcoma With CDK4 Amplifications: Results From the Targeted Agent and Profiling Utilization Registry Study.

Scott Schuetze, Michael Rothe, Pam K Mangat...

https://pubmed.ncbi.nlm.nih.gov/39013131

Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study.

Gordan Srkalovic, Michael Rothe, Pam K Mangat...

https://pubmed.ncbi.nlm.nih.gov/38865672

Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

Timothy L Cannon, Michael Rothe, Pam K Mangat...

https://pubmed.ncbi.nlm.nih.gov/38748939

Concordance in Molecular Tumor Board Case Reviews in the ASCO TAPUR Study.

Jacqueline K Perez, Jeanene Kleber, Michael Rothe...

https://pubmed.ncbi.nlm.nih.gov/38564684

Targeted Agent and Profiling Utilization Registry (TAPUR) Study

On this page

Sponsors

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

AI-Screening

AI-Powered Screening

Your Study Journey

Trial Site Locations

Research Team

How is the study designed?

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Frequently Asked Questions

What is this study trying to find out about advanced cancer?

Who may be eligible for this advanced cancer clinical trial?

Is there any cost to participate in this advanced cancer clinical trial?

How are participants assigned to study groups?

How will the study measure treatment effects on cancer?

What happens after this advanced cancer clinical trial ends?

Can I leave this advanced cancer clinical trial if I change my mind?

Not the Right Trial for You?

Published Research Related To This Trial

Nivolumab Plus Ipilimumab in Patients With Solid Tumors With High Tumor Mutation Burden: Results From the Targeted Agent and Profiling Utilization Registry Study.

Temsirolimus in Patients With Solid Tumors With PIK3CA Mutations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Olaparib in Patients With Solid Tumors With BRCA1/2 Alterations: Results From The Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Prevalence of targetable genomic alterations among a diverse population participating in the ASCO TAPUR Study.

Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

Palbociclib in Patients With Soft Tissue Sarcoma With CDK4 Amplifications: Results From the Targeted Agent and Profiling Utilization Registry Study.

Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study.

Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

Concordance in Molecular Tumor Board Case Reviews in the ASCO TAPUR Study.

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