Actively Recruiting
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
Led by Target ALS Foundation, Inc. · Updated on 2025-11-21
1000
Participants Needed
12
Research Sites
552 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information that are made available to the research community. To accomplish these goals, we will enroll 800 Amyotrophic Lateral Sclerosis (ALS) patients and 200 healthy controls from sites globally, over a 5 year time frame. Additionally, speech and motor function and spirometry measures will be collected bi-weekly in a subset of participants. ALS participants will be asked to come to the clinic for 5 study visits approximately every 4 months. Healthy participants will be coming for 2 study visits with a 12-month interval between visits. These samples and clinical information will be stored in a de-identified manner and made available for investigators to use in future research studies.
CONDITIONS
Official Title
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- For ALS participants: diagnosis of ALS by Gold Coast criteria
- For ALS participants: Full Vital Capacity of 30% or higher or approved by Principal Investigator
- Ability to provide informed consent and understand study risks and purpose
- Ability to comply with study procedures as judged by Principal Investigator
- For healthy controls: no history of neurological disease
- For healthy controls: no known ALS-associated genetic mutations at consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
Actively Recruiting
2
University of California San Diego
San Diego, California, United States, 92121
Actively Recruiting
3
Georgetown University
Georgetown, District of Columbia, United States, 20007
Actively Recruiting
4
Mayo Clinic
Jacksonville, Florida, United States, 32224
Actively Recruiting
5
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
6
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
7
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
8
Columbia University
New York, New York, United States, 10032
Actively Recruiting
9
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
10
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
11
Instituto Roosevelt
Bogotá, Colombia
Actively Recruiting
12
CHALS-CCT UPR MScience
San Juan, Puerto Rico, 00935
Actively Recruiting
Research Team
L
Laura Dugom, MPH
CONTACT
R
Robert Bowser, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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