Actively Recruiting
Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation
Led by M.D. Anderson Cancer Center · Updated on 2025-09-05
45
Participants Needed
1
Research Sites
338 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial evaluates two surgical techniques (targeted muscle re-innervation \[TMR\] and regenerative peripheral nerve interfaces \[RPNI\]) alone and in combination for the alleviation of chronic residual limb and phantom limb pain in cancer patients who have had an amputation. Chronic residual limb pain and phantom limb pain are debilitating outcomes of traumatic and oncologic amputation. Emerging microsurgical treatments for post-amputation pain are very promising. TMR and RPNI are both approved surgical techniques that involve connecting cut nerves to parts of the muscle as a way to heal and protect the nerves. This trial evaluates these techniques alone and in combination for the treatment of residual and phantom limb pain in cancer patients who have received an amputation.
CONDITIONS
Official Title
Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older who are receiving an amputation for cancer reasons
- Patients with available mixed major nerves and donor motor nerves in the amputation stump or reconstructive tissue
- Patients able to complete informed consent
You will not qualify if you...
- Patients under 18 years of age
- Patients unable to give consent
- Patients receiving an amputation for non-cancer reasons
- Patients receiving amputation for immediate palliation with life expectancy less than 3 months
- Patients with multiple limb amputations
- Patients who had previous amputation and present with neuroma or nerve management done in delayed fashion
AI-Screening
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Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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