Actively Recruiting
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Led by Peking University First Hospital · Updated on 2025-07-30
612
Participants Needed
1
Research Sites
411 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI. In a recent randomized controlled trial of patients undergoing major noncardiac surgery, intraoperative individualized blood-pressure management reduced the incidence of postoperative organ dysfunction. The investigators hypothesize that, for patients undergoing off-pump CABG, targeted blood-pressure management during surgery may also reduce the incidence of postoperative AKI.
CONDITIONS
Official Title
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 50 years
- Scheduled to undergo off-pump coronary artery bypass grafting (CABG) surgery
You will not qualify if you...
- Refuse to participate
- Untreated or uncontrolled severe hypertension (systolic blood pressure 65180 mmHg or diastolic blood pressure 65110 mmHg)
- Chronic kidney disease with a glomerular filtration rate < 30 ml/min/1.73 m2 or end-stage renal disease requiring renal-replacement therapy
- Unable to communicate during preoperative period due to coma, profound dementia, language barrier, or end-stage disease
- Need vasopressors or inotropics to maintain blood pressure before surgery
- Undergoing second or emergency surgery
- Expected survival less than 24 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
L
Li Huang, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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