Actively Recruiting

Phase Not Applicable
Age: 1Day - 21Days
All Genders
NCT04294368

Targeted Fortification of Donor Breast Milk in Preterm Infants

Led by Columbia University · Updated on 2026-04-07

50

Participants Needed

1

Research Sites

364 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study is a randomized controlled trial comparing standard fortification of donor breast milk to targeted fortification of donor breast milk in preterm infants. The purpose of the study is to determine if there is a benefit to target fortifying donor breast milk in the preterm population. The investigators hypothesize that infants receiving targeted fortification of donor breast milk will have improved growth compared to infants receiving standard fortification of donor breast milk.

CONDITIONS

Official Title

Targeted Fortification of Donor Breast Milk in Preterm Infants

Who Can Participate

Age: 1Day - 21Days
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Premature infants born </= 30 weeks gestational age
  • Birth weight </= 1500 grams
Not Eligible

You will not qualify if you...

  • Parents do not consent to donor milk
  • Presence of confounding conditions for poor growth such as congenital heart disease, gastroschisis, omphalocele, or major congenital anomalies
  • Grade III or IV intraventricular hemorrhage diagnosed before randomization
  • Small for gestational age (less than 3% on Fenton Growth Curve)
  • Failure to start fortified feeds before 3 weeks of age
  • Diagnosis of necrotizing enterocolitis before randomization
  • Diagnosis of early onset sepsis confirmed with positive culture

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Columbia University Medical Center/ New York - Presbyterian

New York, New York, United States, 10032

Actively Recruiting

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Research Team

M

Marianne Garland, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Targeted Fortification of Donor Breast Milk in Preterm Infants | DecenTrialz