Actively Recruiting
Targeted Genomic Analysis of Human Cancers
Led by Rutgers, The State University of New Jersey · Updated on 2026-04-17
1100
Participants Needed
11
Research Sites
N/A
Total Duration
On this page
Sponsors
R
Rutgers, The State University of New Jersey
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying targeted genomic analysis of blood and tissue samples from patients with cancer, focusing on rare cancers with poor prognosis or limited treatment options. This observational research aims to identify genetic changes using genomic sequencing to help understand cancer development and to provide clinicians with mutation data that may guide treatment or referral to relevant studies. The study also collects clinical outcomes and tumor genome data for future analysis and cancer model development. The study involves analyzing previously collected tumor tissue samples using next-generation sequencing to detect mutations. Patients may also provide blood samples for analysis of circulating cell-free DNA and circulating tumor cells. These procedures support the identification of actionable mutations that may have available targeted therapies. The research includes correlative laboratory biomarker analysis. Participants are followed after study completion every 3 months for 2 years, then every 6 months for up to 15 years to monitor clinical outcomes and mutation frequencies. Researchers measure the frequency of specific mutations and the rate of actionable mutations in rare or poor prognosis cancers over this period. This long-term follow-up helps correlate genomic findings with patient outcomes and supports future research developments.
CONDITIONS
Brief Title
Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Karnofsky or Lansky performance score of 30 or higher
- Signed written informed consent
- Evaluation in oncology or radiology clinic with biopsy-confirmed rare cancer or cancer with poor prognosis
- Priority given to rare cancers with poor prognosis and lack of effective standard therapy
- Availability and accessibility of paraffin tumor tissue blocks for analysis
You will not qualify if you...
- Karnofsky or Lansky performance score less than 30
- Life expectancy less than 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week
Participants provide previously collected tumor tissue samples and may undergo blood sample collection for genomic analysis.
1 visit (in-person) for blood sample collection; tissue samples are previously collected
Duration - Up to 15 years
Participants are followed up to collect clinical outcomes and monitor genomic data every 3 months for 2 years, then every 6 months for up to 15 years.
Follow-up visits every 3 months for 2 years, then every 6 months for up to 15 years
Trial Site Locations
Total: 11 locations
1
Ocean Medical Center
Brick, New Jersey, United States, 08724
Completed
2
Bayshore Community Hospital
Holmdel, New Jersey, United States, 07733
Completed
3
RWJBarnabas Health - Jersey City Medical Center, Jersey City
Jersey City, New Jersey, United States, 07302
Actively Recruiting
4
Southern Ocean County Medical Center
Manahawkin, New Jersey, United States, 08050
Completed
5
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Completed
6
Jersey Shore Medical Center
Neptune City, New Jersey, United States, 07753
Completed
7
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
8
Riverview Medical Center/Booker Cancer Center
Red Bank, New Jersey, United States, 07701
Completed
9
Riverview Medical Center
Red Bank, New Jersey, United States, 07701
Active, Not Recruiting
10
Overlook Hospital
Summit, New Jersey, United States, 07902
Completed
11
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792
Withdrawn
Research Team
C
Clinical Trials Office
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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