Effect of Daily Targeted Nutrient Supplement on Physical Activity and Quality of Life in Adults with COPD

What this Trial Is About

Researchers are evaluating the effects of targeted nutrient supplementation on daily physical activity levels and overall health status in patients with chronic obstructive pulmonary disease COPD. The study also aims to assess how this supplementation influences recovery after hospitalization for a COPD exacerbation. Secondary goals include examining impacts on mental health, physical performance, blood markers, patient-reported outcomes, and gut health, as well as comparing the gut microbiome of COPD patients to healthy controls. Participants include COPD patients randomly assigned to receive either a daily targeted nutrient supplement in a long-drink form or an isocaloric placebo, both accompanied by monthly healthy lifestyle counseling focusing on physical activity, smoking cessation, and weight management. The intervention lasts at least 12 months. Additionally, healthy controls will undergo baseline measurements for microbiome comparison but will not receive supplements or counseling. During the study, participants will have their physical activity monitored through step counts and complete health questionnaires at the beginning, three months, and between twelve to fourteen months, with additional assessments after any COPD-related hospitalizations. Researchers will perform a range of tests including cognitive function assessments, mental health scales, physical performance tests, blood sampling, body composition scans, and gut microbiome analysis. These evaluations help measure changes in health and recovery over time while monitoring safety and adherence.

Targeted Nutrient Supplement in COPD (NUTRECOVER-trial)