Actively Recruiting
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
Led by Duke University · Updated on 2026-03-19
15
Participants Needed
1
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to support power calculations for a larger research study.
CONDITIONS
Official Title
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persons with early Rheumatoid Arthritis diagnosed 6 months ago or less and not on biologic DMARD therapy
- May be on one or more conventional synthetic DMARDs such as hydroxychloroquine, methotrexate, sulfasalazine, leflunomide, or azathioprine
- Positive rheumatoid factor or anti-citrullinated protein antibody, or typical erosions on X-rays
- History of meeting 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis
- Active Rheumatoid Arthritis with Clinical Disease Activity Index (CDAI) greater than 2.8
- Stable doses of all Rheumatoid Arthritis and cardiovascular risk-related medications for at least 1 month, except glucocorticoids
You will not qualify if you...
- Pregnant or planning pregnancy during the intervention period
- Currently treated with exogenous insulin
- Having other inflammatory joint or muscle diseases such as Paget's disease, pigmented villonodular synovitis, joint infections, ochronosis, neuropathic arthropathy, osteochondromatosis, acromegaly, hemochromatosis, or Wilson's disease
- Current cancer except minor invasive carcinomas treated topically or with minor surgery
- Absolute contraindications to exercise including unstable angina, uncontrolled dangerous heart rhythms, active endocarditis, severe aortic valve narrowing, heart failure, recent pulmonary embolism or deep vein thrombosis, myocarditis, pericarditis, aortic dissection, or physical disabilities preventing safe exercise
- Relative exercise contraindications such as certain heart artery blockages, severe valve problems, uncontrolled heart rhythm issues, advanced heart block, severe hypertrophic cardiomyopathy, recent stroke or mini-stroke, mental impairments limiting cooperation, or uncontrolled medical conditions like severe hypertension, anemia, electrolyte imbalances, or hyperthyroidism
- Heart attack within the past six months
- High resting blood pressure with systolic or diastolic values at or above 180/110 mm Hg
- Lack of internet access
- Planned intentional weight loss during the study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
J
Johanna Johnson, MS
CONTACT
B
Brian J Andonian, MD, MHSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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