Actively Recruiting
TARGETed Therapy Drug MONITOring in DIGestive Oncology
Led by UNICANCER · Updated on 2025-03-30
330
Participants Needed
29
Research Sites
248 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Targeted therapy drug monitoring in digestive oncology: Dosage of plasma levels of various multikinase inhibitors (MKI) in patients treated for advanced digestive cancer (gastrointestinal stromal tumor (GIST), metastatic colorectal cancer (mCRC), hepatocellular carcinoma (HCC), gastroenteropancreatic neuroendocrine tumor (gepNET), or pancreatic neuroendocrine tumor (pNET)), with the aim of determine the optimal dose adapted for each patient, in the future.
CONDITIONS
Official Title
TARGETed Therapy Drug MONITOring in DIGestive Oncology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 years or over
- Advanced digestive cancer confirmed by histology or imaging for HCC
- Planned standard treatment with regorafenib for GIST, mCRC, or HCC
- Planned standard treatment with everolimus for gastroenteropancreatic neuroendocrine tumor
- Planned standard treatment with sunitinib for pancreatic neuroendocrine tumor or GIST
- Planned standard treatment with cabozantinib for HCC
- Planned standard treatment with encorafenib-cetuximab for metastatic colorectal cancer
- Life expectancy greater than 3 months as judged by the investigator
- Measurable disease by tumor evaluation criteria per local practice
- Affiliated to a Social Security System or equivalent
- Signed informed consent form prior to trial procedures
You will not qualify if you...
- Receiving other anticancer systemic treatments besides the study drugs
- Unresolved toxicity higher than Grade 1 from prior therapies except alopecia and peripheral neuropathy
- Prior treatment with the same multikinase inhibitor planned in the study
- Other invasive malignancies active or within last 3 years except certain treated skin or cervical cancers
- Conditions that may risk study participation including lack of contraception for those with child-bearing potential, pregnancy, or breastfeeding
- Unable or unwilling to comply with required medical follow-up and pharmacokinetic sampling
- Participation in another clinical trial with an investigational drug within 30 days prior to inclusion
- Patient deprived of liberty or under protective custody or guardianship
AI-Screening
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Trial Site Locations
Total: 29 locations
1
CHU d'Amiens Pcardie - Hopital Sud
Amiens, France
Actively Recruiting
2
CH d'Auxerre
Auxerre, France
Actively Recruiting
3
Institut du Cancer Avignon - Institut Sainte Catherine
Avignon, France
Withdrawn
4
CH de Bayeux - Onconormandie
Bayeux, France
Withdrawn
5
Centre Jean Perrin
Clermont-Ferrand, France
Actively Recruiting
6
Hôpital Beaujon APHP
Clichy, France
Actively Recruiting
7
Centre Georges Francois Leclerc
Dijon, France
Withdrawn
8
Institut de Cancérologie de Bourgogne
Dijon, France
Actively Recruiting
9
CH Eure Seine - Hopital d'Evreux Vernon
Évreux, France
Not Yet Recruiting
10
Centre Oscar Lambret
Lille, France
Actively Recruiting
11
Groupement des hôpitaux de l'Institut Catholique de Lille - Hôpital Saint Vincent de Paul
Lille, France
Not Yet Recruiting
12
Centre Léon Bérard
Lyon, France
Withdrawn
13
Hôpital Européen Marseille
Marseille, France
Not Yet Recruiting
14
CHRU de Nancy - Hôpital de Brabois Adulte
Nancy, France
Actively Recruiting
15
CHU de Nantes - Hôtel Dieu
Nantes, France
Actively Recruiting
16
Centre Antoine Lacassagne
Nice, France
Withdrawn
17
APHP Pitié Salpétrière
Paris, France
Actively Recruiting
18
Hôpital Saint Joseph
Paris, France
Actively Recruiting
19
Institut Mutualiste de Montsouris
Paris, France
Actively Recruiting
20
Hôpital Privé des Côtes d'Armor - SAS
Plérin, France
Actively Recruiting
21
CHU de Poitiers
Poitiers, France
Not Yet Recruiting
22
CHU de Reims - Hôpital Robert Debré
Reims, France
Actively Recruiting
23
Institut Jean Godinot
Reims, France
Actively Recruiting
24
Centre Eugène Marquis
Rennes, France
Not Yet Recruiting
25
CHU Rouen - Hôpital Charles Nicolle
Rouen, France
Actively Recruiting
26
CH Saint Malo - Hôpital Broussais
St-Malo, France
Actively Recruiting
27
ICANS
Strasbourg, France
Actively Recruiting
28
CHU de Tours
Tours, France
Actively Recruiting
29
Gustave Roussy
Villejuif, France
Actively Recruiting
Research Team
M
Michaël CHEVROT, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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