Actively Recruiting
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
Led by Children's Hospital of Philadelphia · Updated on 2025-11-14
32
Participants Needed
9
Research Sites
602 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Philadelphia
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that block many of the genetic drivers of DTC have become available. While Investigators know that these drugs shrink DTC tumors in many cases, the impact on radioactive iodine (RAI) avidity has not been systematically studied.
CONDITIONS
Official Title
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a histologic diagnosis of differentiated thyroid cancer
- Presence of targetable genetic alterations such as NTRK-fusion, RET-fusion, ALK-fusion, BRAF V600 mutation, or BRAF-fusion identified in a certified laboratory
- Anatomically evaluable lung metastases on chest CT within 180 days before enrollment, including multiple (10 or more) noncalcified solid pulmonary nodules or enlarging discrete pulmonary nodules consistent with metastatic disease
- Planned systemic therapy with an oncogene-specific kinase inhibitor from commercial supply or as part of a separate therapeutic trial, compassionate use, or single patient IND
- Patients enrolled on other oncogene-specific targeted therapy trials who have whole body thyroid scans about 28 days after starting therapy and agree to data sharing
You will not qualify if you...
- Prior oncogene-specific targeted therapy is not allowed, except enrollment within 4 weeks of starting therapy if a pre-therapy whole body scan is available
- Females who are pregnant or breastfeeding
- Patients requiring sedation or general anesthesia to complete a whole body scan
- U.S. Military personnel are excluded due to institutional review board requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
2
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
Actively Recruiting
3
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
4
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
5
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
6
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
7
Texas Children's Hospital
Houston, Texas, United States, 77030
Actively Recruiting
8
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
9
Children's Hospital Westmead
Sydney, New South Wales, Australia
Actively Recruiting
Research Team
M
Meghan T Donnelly
CONTACT
J
James Robinson
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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