Actively Recruiting
Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities
Led by University of Nebraska · Updated on 2026-03-25
80
Participants Needed
1
Research Sites
465 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study will test whether a form of non-invasive brain stimulation repetitive transcranial magnetic stimulation (rTMS) can improve memory abilities in healthy young adults, healthy older adults, and older adults with aMCI by retuning memory-related brain networks. This study is a key first step which will support the long-term goal of treating memory deficits in neurological patients. It is expected that rTMS will improve memory abilities in all participants, and that the improvements in memory will be attributable to changes in the connectivity of memory-related brain networks.
CONDITIONS
Official Title
Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 19 years of age and older
- Healthy adults without a history of psychiatric or neurological disease or with a previous diagnosis of amnestic mild cognitive impairment
- Able to provide informed consent
- Able to follow basic instructions and sit comfortably still during TMS, neuroimaging, and other study procedures
- Right-handed based on self-report and a standard test
You will not qualify if you...
- Presence of ferrous metal implants in the body (excluding teeth) or any other non-removable medical or metallic implant
- Increased intracranial pressure
- Any major medical illness such as cancer, HIV positive status, hepatitis, or heart disease
- Confounding or dual diagnoses like comorbid mental illness and substance use disorder
- Current diagnosis of alcohol or substance abuse or dependence
- Epilepsy, history of seizures, or use of medication reducing seizure threshold
- Any neurological disorder other than amnestic mild cognitive impairment, including stroke or traumatic brain injury
- Pregnancy as confirmed by urine pregnancy test
- Not right-handed based on self-report or evaluation
- Not a native English speaker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
Research Team
A
Anna Wilhelm, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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