Actively Recruiting
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Led by University of Texas Southwestern Medical Center · Updated on 2026-05-07
78
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
CONDITIONS
Official Title
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signs and symptoms of heart failure
- An ejection fraction greater than 0.50
- Objective evidence of diastolic dysfunction, elevated biomarkers (NT-proBNP >300 ng/dl), or heart failure hospitalization
- Healthy volunteers
You will not qualify if you...
- Age less than 55 years
- Body mass index greater than 50 kg/m2
- Atrial fibrillation with poorly controlled heart rate
- Use of phosphodiesterase type 5 (PDE5) inhibitors
- Severe valvular disease
- Severe chronic obstructive pulmonary disease (COPD)
- Chronic kidney disease stage 4 or higher
- Any restriction of ambulation and mobility
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
R
Raksa B Moran, RN
CONTACT
J
Jessica N Alcala, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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