Actively Recruiting
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment - A Prospective Study
Led by Chang Gung Memorial Hospital · Updated on 2024-07-16
130
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute heart failure is a serious condition that causes significant health problems and death worldwide. Researchers are studying the effects of a multidisciplinary cardiac rehabilitation program combined with monitoring specific markers like LOXl2, cardiac MRI, and endothelial function to better understand how these factors may help improve outcomes after acute heart failure. This observational study follows patients discharged after acute heart failure to investigate these predictors and the potential benefits of rehabilitation. Participants in the study receive a multi-disciplinary disease management program including exercise-based cardiac rehabilitation. This involves treadmill walking, cycling, stair climbing, or elliptical training, with sessions three times a week for a total of 36 sessions. Exercise intensity is gradually increased based on individual testing. Cardiac MRI scans and blood tests measuring LOXl2 and endothelial function are performed. A cardiopulmonary exercise test is also conducted after discharge to guide phase II rehabilitation. During the study, participants will have follow-up visits to monitor heart function, LOXl2 levels, and endothelial function at 6 months. Researchers will also track all-cause mortality and hospital readmissions for heart failure up to 36 months. Secondary outcomes include quality of life scores and peak oxygen consumption. The study aims to evaluate how cardiac rehabilitation can influence cardiac fibrosis and improve patient outcomes over time, with ongoing monitoring and assessments throughout the study period.
CONDITIONS
Brief Title
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must give written informed consent before any assessment is performed.
- Inpatients aged 20 years or older, male or female.
- Diagnosis of heart failure New York Heart Association (NYHA) class II to IV with BNP ≥100 pg/mL or NT-proBNP ≥400 pg/mL (≥900 pg/mL if with atrial fibrillation).
- Left ventricular ejection fraction ≤ 40% by echocardiography or other methods.
You will not qualify if you...
- Estimated survival time less than 6 months.
- Long-term bedridden for more than 3 months.
- Unable to tolerate exercise test due to musculoskeletal disorder.
- Unable to cooperate with all functional studies.
- Ventilator dependent.
- Terminal heart status.
- Family rejects participation.
- Primary severe valvular heart disease.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 months
Participants undergo exercise-based cardiac rehabilitation, which includes treadmill walking, cycling, stair climbing, or elliptical machine training. Training sessions last 40 minutes including warm-up and cool-down exercises, conducted three times per week for a total of 36 sessions.
Three sessions per week for up to 12 weeks
Duration - Up to 36 months
Participants are followed up to assess endothelial function, LOXl2 levels, cardiac fibrosis via MRI, and quality of life measures. Outcomes such as all-cause mortality and heart failure readmission are also monitored.
Follow-up visits at 6, 12, and up to 36 months
Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital Heart Failure Center
Kaohsiung City, Taiwan, 83341
Actively Recruiting
Research Team
H
Hsin-Yen Tsai
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here