Actively Recruiting
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
Led by Chang Gung Memorial Hospital · Updated on 2024-07-16
130
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.
CONDITIONS
Official Title
Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must give written informed consent before any assessment is performed.
- Inpatients 20 years of age or older, male or female.
- Diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP 60;100 pg/mL or NT-proBNP 60;400 pg/mL (60;900 pg/mL if atrial fibrillation present).
- Left ventricular ejection fraction 60;40% by echocardiography or other methods.
You will not qualify if you...
- Estimated survival time less than 6 months.
- Long-term bedridden for more than 3 months.
- Unable to tolerate exercise test due to muscular skeletal disorders.
- Unable to cooperate with all functional studies.
- Ventilator dependent.
- Terminal heart status.
- Family refuses participation in the project.
- Primary severe valvular heart disease.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital Heart Failure Center
Kaohsiung City, Taiwan, 83341
Actively Recruiting
Research Team
H
Hsin-Yen Tsai
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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