Actively Recruiting
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose
Led by Stanford University · Updated on 2026-01-20
24
Participants Needed
1
Research Sites
415 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to target the neurobiology of restricted and repetitive behaviors in children with autism spectrum disorder using N-acetylcysteine (NAC), a well-tolerated nutritional supplement that has shown promise for reducing symptom severity in recent small-scale trials. The findings from this research will shed light on the mechanisms of action underlying the clinical benefits of NAC.
CONDITIONS
Official Title
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children between 3 years and 12 years 11 months at the time of consent
- Diagnosis of Autism Spectrum Disorder confirmed with ADI-R and ADOS-2, or BOSA, or CARS-2
- At least moderate restricted and repetitive behaviors severity (Children's Yale-Brown Obsessive Compulsive Scale score 63; 11)
- Physical development indicative of prepubescence (Tanner Stage 1)
- Medically stable
- Passes MR safety screening (no metal in the body)
You will not qualify if you...
- Known genetic abnormalities associated with Autism Spectrum Disorder (e.g., Fragile X)
- Current or lifetime diagnosis of severe psychiatric disorder (e.g., schizophrenia)
- Significant medical problems that interfere with participation
- At least one caregiver unable to speak/read English sufficiently to complete study requirements
- Taking antioxidant agents and glutathione prodrugs
- Unable or unwilling to swallow an agent during the screening visit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University School of Medicine
Stanford, California, United States, 94305
Actively Recruiting
Research Team
B
Brianna Alconcher
CONTACT
J
John Hegarty, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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