Actively Recruiting
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
Led by Massachusetts Eye and Ear Infirmary · Updated on 2025-09-29
45
Participants Needed
1
Research Sites
345 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
CONDITIONS
Official Title
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 21 years of age or older at time of surgical evaluation
- Diagnosis of advanced FECD and visually significant cataract
- Indication for combined Descemet Membrane Endothelial Keratoplasty (DMEK) and cataract surgery
- Written informed consent obtained and ability to comply with study requirements
- Willingness and ability to follow the medication regimen
You will not qualify if you...
- Pregnant, breastfeeding, or unwilling to use birth control during study participation
- History of prior intraocular surgery in the study eye, including cataract, glaucoma, or retina surgery
- History of other corneal diseases such as severe dry eye, corneal scars, pseudophakic bullous keratopathy, corneal degenerations, or infections
- Use of ocular prescription medications except lubricants, hyperosmotic agents, or ocular hypotensive agents
- History of ocular surface infection within the past 30 days
- Use of systemic, inhalational, or topical N-Acetylcysteine within the past 30 days
- History of intolerance to topical N-Acetylcysteine
- Any condition or abnormality that may compromise patient safety or data quality according to the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
M
Michael Cheung, MSc, CCRP
CONTACT
U
Ula Jurkunas, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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