Actively Recruiting
Led by University of Tasmania · Updated on 2023-10-30
3000
Participants Needed
1
Research Sites
260 weeks
Total Duration
U
University of Tasmania
Lead Sponsor
N
National Health and Medical Research Council, Australia
Collaborating Sponsor
Researchers are evaluating a new online motor-cognitive test called the TAS Test to detect early signs of Alzheimer's disease (AD) before cognitive symptoms appear. AD usually develops silently over 10-20 years during a preclinical phase, and early detection is important to offer interventions before irreversible brain damage occurs. This observational study aims to create a scalable, non-invasive test that people can take from home using their computers, combining hand-movement analysis with cognitive assessments and blood biomarkers. The study consists of two parts: Sub-study 1 will recruit 500 participants over 50 years old with normal cognition from existing cohorts to complete the TAS Test online or in a research center at baseline, 3 months, and 6 months. Blood samples will measure a biomarker called p-tau181. Sub-study 2 will involve 10,000 adults who will complete the TAS Test every 6 months and cognitive tests every 24 months at home over 5 years. The researchers will use the data to develop an algorithm that predicts risk of cognitive decline and Alzheimer's disease. Participants will complete online motor and cognitive tests from home, with some visits for blood tests and clinical diagnosis in a smaller group. The study will monitor changes in hand movements, cognitive scores, and blood markers over time to validate the TAS Test's ability to predict Alzheimer's risk. The research includes follow-up over 3 to 5 years to assess cognitive decline and diagnosis outcomes, providing a comprehensive evaluation of this new testing approach.
CONDITIONS
TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for eligibility confirmation and baseline blood test
Duration - Baseline visit plus 6 months
Participants complete online motor-cognitive tests and have baseline blood biomarker assessments to evaluate cognitive status and detect pre-Alzheimer's disease changes.
3 visits (baseline, 3 months, and 6 months) completed online or at the research centre
Duration - Up to 5 years
Participants complete online motor-cognitive tests every 6 months and undergo cognitive assessments every 24 months to monitor changes over time and validate risk predictions.
Online visits every 6 months for TAS Test and every 24 months for CANTAB assessments
Total: 1 location
1
University of Tasmania
Hobart, Tasmania, Australia, 7001
Actively Recruiting
A
A/Prof Alty, MD FRACP
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Jane Alty, Quan Bai, Renjie Li...
https://pubmed.ncbi.nlm.nih.gov/35850660