Online Motor-Cognitive Testing to Detect Early Signs of Alzheimers Disease in Adults Over 50

What this Trial Is About

Researchers are evaluating a new online motor-cognitive test called the TAS Test to detect early signs of Alzheimers disease AD before cognitive symptoms appear. AD usually develops silently over 10-20 years during a preclinical phase, and early detection is important to offer interventions before irreversible brain damage occurs. This observational study aims to create a scalable, non-invasive test that people can take from home using their computers, combining hand-movement analysis with cognitive assessments and blood biomarkers. The study consists of two parts Sub-study 1 will recruit 500 participants over 50 years old with normal cognition from existing cohorts to complete the TAS Test online or in a research center at baseline, 3 months, and 6 months. Blood samples will measure a biomarker called p-tau181. Sub-study 2 will involve 10,000 adults who will complete the TAS Test every 6 months and cognitive tests every 24 months at home over 5 years. The researchers will use the data to develop an algorithm that predicts risk of cognitive decline and Alzheimers disease. Participants will complete online motor and cognitive tests from home, with some visits for blood tests and clinical diagnosis in a smaller group. The study will monitor changes in hand movements, cognitive scores, and blood markers over time to validate the TAS Tests ability to predict Alzheimers risk. The research includes follow-up over 3 to 5 years to assess cognitive decline and diagnosis outcomes, providing a comprehensive evaluation of this new testing approach.

TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease