Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06669416

Taste Alterations Study

Led by Wake Forest University Health Sciences · Updated on 2025-11-21

400

Participants Needed

1

Research Sites

73 weeks

Total Duration

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AI-Summary

What this Trial Is About

The main questions it aims to answer are: 1. Does completing a standard assessment increase the detection of chemotherapy induced taste changes compared with usual care (no assessment)? What TA are experienced? Are there any patterns in TA symptom occurrence based on age, sex, race/ethnicity, cancer type, chemotherapy agent, etc. 2. Do patients take action to deal with the TA? What strategies are used? Do patients in the intervention group use the assessments to select interventions? 3. Do the interventions lessen TA symptoms and maintain food intake? Is the treatment (in-depth assessment and education) more effective in lessening the intensity of TA than usual care? Which level of assessment is needed to support symptom management to reduce symptom severity? Participants will: Complete baseline assessment before starting their initial chemotherapy infusion (all patients) Participate in baseline patient education based on assigned intervention (usual care vs. treatment) Engage in TA management between chemotherapy infusion clinic visits based on education Visit the clinic for chemotherapy infusions as scheduled; Complete TA assessments and reporting based on intervention; Work with nurse coaches to answer questions and help with the intervention. Complete study data collection on the 4th chemotherapy cycle (but continue intervention) Complete final data collection at 6 months

CONDITIONS

Official Title

Taste Alterations Study

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Medical diagnosis of cancer with types limited to the top cancer types [Note: Cancer types that are rare will be excluded]
  • Initiating chemotherapy (first day/first cycle) at participating clinics
  • English speaking/reading (without an interpreter)
Not Eligible

You will not qualify if you...

  • Substitute decision-maker (activated)
  • History of head/neck cancer or irradiation
  • Known genetic/metabolic disorder impacting taste (preexisting dysgeusia)
  • Known eating disorder
  • Receiving enteral or parenteral nutrition (special nutritional needs)
  • Pregnant women (unique needs)
  • Patients with medical orders for end of life/hospice care

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States, 60657

Actively Recruiting

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Research Team

M

Mary L Hook, PhD, RN

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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