Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID06669416

Effects of Patient Education and Self-Management in Cancer Patients Who Experience Chemotherapy-Induced Taste Alterations

Led by Wake Forest University Health Sciences · Updated on 2026-05-22

400

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to improve understanding and management of taste changes caused by chemotherapy in adult cancer patients. It evaluates whether adding a nurse-led, detailed taste alteration assessment and education helps patients detect and manage these taste changes better than usual care. The study includes a diverse group of cancer patients undergoing chemotherapy, focusing on taste alteration symptoms, patient actions, and dietary intake. Participants receive care based on their clinic's assignment: usual care or an intervention with nurse-led self-assessment and self-management of taste alterations. The intervention uses a validated taste assessment tool (Chemotherapy-induced Taste Alterations Scale) and patient education materials to help manage symptoms. Usual care includes standard chemotherapy education and a simple taste alteration severity question. Data collection occurs before chemotherapy starts, through the first four chemotherapy cycles, and continues for six months. Participants complete baseline assessments and patient education, report taste alteration symptoms during chemotherapy visits, and work with nurse coaches. The study tracks taste alteration severity, patient interventions, dietary intake, and body mass index over six months. Data collection and patient support continue throughout the chemotherapy cycles and follow-up period to assess the intervention's impact on symptom management and nutrition.

CONDITIONS

Brief Title

Taste Alterations Study

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Medical diagnosis of cancer with types limited to the top cancer types
  • Initiating chemotherapy (first day/first cycle) at participating clinics
  • English speaking and reading without an interpreter
Not Eligible

You will not qualify if you...

  • Substitute decision-maker (activated)
  • History of head or neck cancer or irradiation
  • Known genetic or metabolic disorder affecting taste (preexisting dysgeusia)
  • Known eating disorder
  • Receiving enteral or parenteral nutrition (special nutritional needs)
  • Pregnant women
  • Patients with medical orders for end of life or hospice care

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - During the first 4 chemotherapy cycles over approximately 6 months

Participants receive chemotherapy and either usual care or a nurse-led intervention involving taste alteration self-assessment and self-management strategies to help manage taste alterations during chemotherapy.

Visits aligned with chemotherapy cycles, approximately 4 cycles over 6 months

Follow-up

Duration - Up to 6 months following treatment initiation

Participants are monitored for taste alteration severity, dietary intake, and body mass index through the completion of the study.

Ongoing assessments during treatment visits up to 6 months

Trial Site Locations

Total: 1 location

1

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States, 60657

Actively Recruiting

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Research Team

M

Mary L Hook, PhD, RN

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

Effects of a self-monitoring intervention in breast cancer patients suffering from taste alterations induced by chemotherapy: A randomized, parallel-group controlled trial.

Taeko Kinjo, Kiyoko Kanda, Keiko Fujimoto

https://pubmed.ncbi.nlm.nih.gov/33940487

Fatigue, Stress, and Functional Status are Associated With Taste Changes in Oncology Patients Receiving Chemotherapy.

Paule V Joseph, Alissa Nolden, Kord M Kober...

https://pubmed.ncbi.nlm.nih.gov/33259906