Actively Recruiting
The TASTY-training Study
Led by University Medical Center Groningen · Updated on 2025-12-02
90
Participants Needed
11
Research Sites
137 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A multicentre non-blinded randomised intervention trial with a parallel cluster design. The multicentre study will be performed at 12 hospitals in the Netherlands. A parallel cluster design per hospital was selected to prevent contact between participants in the same hospital who are randomised into different study arms. Such contact may result in bias as it may allow for patients in the control arm to be informed about elements of taste and smell training. To examine the effect of at-home taste and smell training versus standard care on taste function and other outcome parameters, measurements will take place at baseline (before the training starts), and after 12 weeks. The intervention will take place at home. The control group will receive usual care. Questionnaires will be filled in online at home, while taste and smell tests and saliva collection will be conducted either at home or in the hospital during regular visits. Patients in both study arms are contacted by their dietitian every 3 weeks.
CONDITIONS
Official Title
The TASTY-training Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 70 years
- Plan to be treated with tyrosine kinase inhibitors for the next 12 weeks
- Experiencing taste changes after starting tyrosine kinase inhibitors
- Able to consume solid foods and drinks
- At most 50% of daily calories from oral nutritional supplements
- Oral mucositis grade 2 or lower (per Common Terminology Criteria for Adverse Events v5.0)
- Able to follow all study procedures
- Provided written informed consent
You will not qualify if you...
- Currently pregnant
- History of taste, smell, or saliva problems before tyrosine kinase inhibitor treatment
- Past or current radiotherapy in head and neck area
- Receiving tube feeding or intravenous nutrition
- Participating in another clinical trial targeting taste or smell changes
- Using high-dose corticosteroids for more than 1 month (over 10 mg prednisone daily or equivalent)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
Amsterdam UMC
Amsterdam, Netherlands
Actively Recruiting
2
Rijnstate Ziekenhuis
Arnhem, Netherlands
Not Yet Recruiting
3
Van Weel-Bethesda Ziekenhuis
Dirksland, Netherlands
Not Yet Recruiting
4
Ziekenhuisvoorzieningen Gelderse Vallei
Ede, Netherlands
Actively Recruiting
5
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ
Actively Recruiting
6
Martini Ziekenhuis
Groningen, Netherlands
Actively Recruiting
7
Radboud University medical Center
Nijmegen, Netherlands
Not Yet Recruiting
8
Ikazia Ziekenhuis
Rotterdam, Netherlands
Actively Recruiting
9
Ommelander Ziekenhuis Groningen
Scheemda, Netherlands
Actively Recruiting
10
Maxima Medisch Centrum
Veldhoven, Netherlands
Not Yet Recruiting
11
Isala Klinieken
Zwolle, Netherlands
Not Yet Recruiting
Research Team
J
J. J.A. de Haan, MD, PhD
CONTACT
M
M. D. Douma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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