Actively Recruiting
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
Led by Yaakov Stern · Updated on 2026-02-11
105
Participants Needed
1
Research Sites
495 weeks
Total Duration
On this page
Sponsors
Y
Yaakov Stern
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders. The investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic resonance imaging (fMRI) neural activation patterns, and other cognitive and behavioral measures. By investigating these relationships, the investigators hope to understand the cognitive and behavioral outcomes of tau deposition found in specific brain regions in cognitively normal/mildly cognitively impaired adults. Furthermore, the study aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.
CONDITIONS
Official Title
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 55-90
- Previously received an amyloid PET scan
- Residing near Columbia University Medical Center
- Must be willing and able to participate
You will not qualify if you...
- Have a contraindication to PET such as metallic implants, pacemaker, claustrophobia, or inability to lie flat for one hour
- Pregnant
- Lactating women
- Current, past, or anticipated exposure to radiation
- Significant active physical illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
R
Reshma Babukutty
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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