Actively Recruiting
taVNS for Breast Cancer Pain and Symptom Management
Led by Florida State University · Updated on 2026-03-30
40
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. To evaluate the feasibility and acceptability of a home-based taVNS intervention and follow-up for pain and symptom management in breast cancer survivors. 2. To investigate the impact of taVNS on secondary outcomes, including pain, anxiety, depression, fatigue, and the brain-gut axis (BGA) in breast cancer survivors.
CONDITIONS
Official Title
taVNS for Breast Cancer Pain and Symptom Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 79 years
- Histologically confirmed Stage 0, I, II, or III breast cancer
- Completed primary cancer treatment and on a stable survivorship care plan with no major changes expected
- Experienced pain rated 4 or higher out of 10 for at least ten days in the past month
- Committed to maintaining current treatment plan during the study
- Have reliable internet access
- Willing to provide stool samples and undergo brain imaging (fNIRS)
- Able to read and understand English and provide written informed consent
You will not qualify if you...
- Metastatic breast cancer (Stage IV)
- Current diagnosis of another active cancer
- History of significant cardiac conditions (e.g., bradycardia, arrhythmia, recent myocardial infarction, heart failure)
- Severe psychiatric illness that may affect study adherence
- Active inflammatory or malabsorptive gastrointestinal disorders
- Use of antibiotics, probiotics, or gastrointestinal motility agents within the past 3 months
- Progressive neurological conditions affecting data quality or participation
- History of surgical or pharmacological vagotomy or current implanted vagus nerve stimulation therapy
- Active electronic or metallic implant in the head or neck area
- Pregnant, breastfeeding, or planning pregnancy during the study
- Recent initiation or dose change of pain medications within the past 4 weeks
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Florida State University
Tallahassee, Florida, United States, 32306
Actively Recruiting
Research Team
J
Jie Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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