Actively Recruiting
taVNS + CCT for Neurocognitive Rehab
Led by Medical University of South Carolina · Updated on 2026-04-08
20
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood. Participants will self-administer these treatment in their homes and undergo pre- and post-treatment assessments of thinking abilities and mood and brain MRIs.
CONDITIONS
Official Title
taVNS + CCT for Neurocognitive Rehab
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 45 to 80 years inclusive
- Adequate motor function of dominant hand and verbal abilities to complete assessments
- Access to reliable Wi-Fi and a Bluetooth-enabled mobile phone or tablet with internet
- Self-reported cognitive changes lasting 6 months or more with concern or impact on daily life
- Stable dose of medication(s) for at least 4 weeks before enrollment and expected to remain stable during study
You will not qualify if you...
- Prior diagnosis of Mild Cognitive Impairment, Dementia, or Mild/Major Neurocognitive Disorder
- Contraindications to taVNS such as history of seizures or ear trauma
- Contraindications to MRI including ferromagnetic implants or claustrophobia
- Acute, unstable, or severe neurological, medical, or psychiatric conditions interfering with safe participation or assessments
- Participation in another clinical trial or investigational treatment within last 30 days affecting cognition or mood
- Positive pregnancy test in females still menstruating within past 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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