Actively Recruiting
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
Led by University of Minnesota · Updated on 2025-10-09
40
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD) that support long-term abstinence. This study will allow the investigators to discern whether the pairing of dorsolateral prefrontal cortex (DLPFC) stimulation and cognitive training can lead to improved treatment outcomes as it pertains to executive functioning and maintenance of abstinence. This paired-neuromodulation approach can potentially be used as a therapeutic intervention to decrease relapse probability in addiction. The long-term goal is to develop new addiction treatments that support long-term abstinence. The exploratory goal of this research is to associate genotypes and epigenetic changes with variations in intervention response and clinical outcome. Individual differences in baseline genetic profiles or epigenetic changes over the course of treatment could be associated with treatment response variability.
CONDITIONS
Official Title
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria for alcohol use disorder
- Currently abstinent from alcohol use
- Intend to remain in the Lodging Plus program until the end of the intervention portion of the study
You will not qualify if you...
- Any medical condition or treatment causing neurological problems such as stroke, tumor, or HIV
- Head injury with skull fracture or loss of consciousness over 30 minutes
- Contraindications for tDCS or MRI, including history of seizures, metal implants, pacemakers, pregnancy, or movement disorders
- Primary psychotic disorders like schizophrenia or schizoaffective disorder
- Conditions making study measures hard to perform or interpret
- Primary substance use disorder other than alcohol, caffeine, or nicotine
- Clinical evidence of Wernicke-Korsakoff syndrome
- Left-handedness
- Entrance to the treatment program under court mandate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
J
Jazmin Camchong, PhD
CONTACT
C
Clarista Berg
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here